Abstract
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases which are involved in the proteolytic processing of several components of the extracellular matrix. As a consequence, MMPs are implicated in several physiological and pathological processes, like skeletal growth and remodelling, wound healing, cancer, arthritis, and multiple sclerosis, raising a very widespread interest toward this class of enzymes as potential therapeutic targets. Here, structure-function relationships are discussed to highlight the role of different MMP domains on substrate/inhibitor recognition and processing and to attempt the formulation of advanced guidelines, based on natural substrates, for the design of inhibitors more efficient in vivo.
Keywords: Matrix metalloproteinases, Enzyme-substrate recognition, Enzyme-inhibitor recognition, Structural bases
Current Medicinal Chemistry
Title: Structural Bases for Substrate and Inhibitor Recognition by Matrix Metalloproteinases
Volume: 15 Issue: 22
Author(s): Loretta Aureli, Magda Gioia, Ilaria Cerbara, Susanna Monaco, Giovanni Francesco Fasciglione, Stefano Marini, Paolo Ascenzi, Alessandra Topai and Massimo Coletta
Affiliation:
Keywords: Matrix metalloproteinases, Enzyme-substrate recognition, Enzyme-inhibitor recognition, Structural bases
Abstract: Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases which are involved in the proteolytic processing of several components of the extracellular matrix. As a consequence, MMPs are implicated in several physiological and pathological processes, like skeletal growth and remodelling, wound healing, cancer, arthritis, and multiple sclerosis, raising a very widespread interest toward this class of enzymes as potential therapeutic targets. Here, structure-function relationships are discussed to highlight the role of different MMP domains on substrate/inhibitor recognition and processing and to attempt the formulation of advanced guidelines, based on natural substrates, for the design of inhibitors more efficient in vivo.
Export Options
About this article
Cite this article as:
Aureli Loretta, Gioia Magda, Cerbara Ilaria, Monaco Susanna, Fasciglione Francesco Giovanni, Marini Stefano, Ascenzi Paolo, Topai Alessandra and Coletta Massimo, Structural Bases for Substrate and Inhibitor Recognition by Matrix Metalloproteinases, Current Medicinal Chemistry 2008; 15 (22) . https://dx.doi.org/10.2174/092986708785747490
DOI https://dx.doi.org/10.2174/092986708785747490 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Clinical Herbal Interactions with Conventional Drugs: From Molecules to Maladies
Current Medicinal Chemistry Structures Behind the Amyloid Aggregation of α-Synuclein: An NMR based Approach
Current Protein & Peptide Science Molecular Links Between Endothelial Dysfunction and Neurodegeneration in Alzheimer's Disease
Current Alzheimer Research Madecassic Acid Reduces Fast Transient Potassium Channels and Promotes Neurite Elongation in Hippocampal CA1 Neurons
CNS & Neurological Disorders - Drug Targets Role of Calmodulin in Platelet Receptor Function
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Intraventricular Implant of Encapsulated CNTF-Secreting Fibroblasts Ameliorates Motor Deficits in Aged Rats
Current Aging Science Hypothetical Link Between Infertility and Genetically Modified Food
Recent Patents on Food, Nutrition & Agriculture F508del-CFTR Rescue: A Matter of Cell Stress Response
Current Pharmaceutical Design Transition Metal Complexes of Some Azamacrocycles and Their Use in Molecular Recognition
Current Organic Synthesis Editorial- Update on Current Alzheimer Research
Current Alzheimer Research Latest Advances Towards the Discovery of 5-HT7 Receptor Ligands
Mini-Reviews in Medicinal Chemistry The Radiosensitizing Effect of Olanzapine as an Antipsychotic Medication on Glioblastoma Cell
Current Radiopharmaceuticals Zinc in the Glutamatergic Theory of Depression
Current Neuropharmacology Treatment of Central Nervous System Involvement Associated with Primary Sjogrens Syndrome
Current Pharmaceutical Design An Increase in Aβ42 in the Prefrontal Cortex is Associated with a Reversal-Learning Impairment in Alzheimers Disease Model Tg2576 APPsw Mice
Current Alzheimer Research Nerve Growth Factor: A Focus on Neuroscience and Therapy
Current Neuropharmacology How Real is Intention-To-Treat (ITT) Analysis in Non-Interventional Post Authorization Safety Studies? We Can Do Better
Current Drug Safety Seizures Secondary to Bupropion Misuse/Abuse: Three Cases
Adolescent Psychiatry Body Weight – The Importance of Getting it Right ‘Before’ Becoming Pregnant
Current Nutrition & Food Science Toll-like Receptor 4 Mediates LPS-Induced Release of Nitric Oxide and Tumor Necrosis Factor-α by Embryonal Cardiomyocytes: Biological Significance and Clinical Implications in Human Pathology
Current Pharmaceutical Design