Generic placeholder image

Current Neuropharmacology

Editor-in-Chief

ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Nerve Growth Factor: A Focus on Neuroscience and Therapy

Author(s): Luigi Aloe, Maria Luisa Rocco, Bijorn Omar Balzamino and Alessandra Micera

Volume 13, Issue 3, 2015

Page: [294 - 303] Pages: 10

DOI: 10.2174/1570159X13666150403231920

Price: $65

Abstract

Nerve growth factor (NGF) is the firstly discovered and best characterized neurotrophic factor, known to play a critical protective role in the development and survival of sympathetic, sensory and forebrain cholinergic neurons. NGF promotes neuritis outgrowth both in vivo and in vitro and nerve cell recovery after ischemic, surgical or chemical injuries. Recently, the therapeutic property of NGF has been demonstrated on human cutaneous and corneal ulcers, pressure ulcer, glaucoma, maculopathy and retinitis pigmentosa. NGF eye drops administration is well tolerated, with no detectable clinical evidence of systemic or local adverse effects. The aim of this review is to summarize these biological properties and the potential clinical development of NGF.

Keywords: Clinical trials, NGF, NGF-healing action, treatment, NGF receptors, visual system.

Graphical Abstract

Rights & Permissions Print Export Cite as
© 2024 Bentham Science Publishers | Privacy Policy