Abstract
Kidney disease, whether acute or chronic, represents a major health hazard. Acute kidney injury (AKI) detection is based mainly on serum creatinine, which is considered to delay prompt diagnosis and management, thus increasing substantially patient morbidity and mortality and prolonged hospitalization. Several biomarkers have been evaluated as early prognostic markers of AKI. However, the vast majority of them are still far from being implicated into clinical practice. On the other hand, routine eGFR estimation and proteinuria monitoring have contributed to previous identification of chronic kidney disease (CKD). Hence, more sensitive and specific biomarkers are needed to enable us recognize individuals at increased risk for progression of CKD to end-stage renal disease (ESRD) and occurrence of cardiovascular complications. This review focuses on the most important novel inflammatory biomarkers that have emerged for early prediction, monitoring and management of kidney disease.
Keywords: Acute kidney injury, biomarker, chronic kidney disease, inflammation, cardiovascular mortality, malnutrition, protein- energy wasting.
Current Medicinal Chemistry
Title:The Importance of Novel Inflammatory Biomarkers in Renal Disease
Volume: 22 Issue: 23
Author(s): S. Marinaki, C. Skalioti, Gerasimos Siasos, Athanasios G Papavassiliou, Dimitris Tousoulis and J.N. Boletis
Affiliation:
Keywords: Acute kidney injury, biomarker, chronic kidney disease, inflammation, cardiovascular mortality, malnutrition, protein- energy wasting.
Abstract: Kidney disease, whether acute or chronic, represents a major health hazard. Acute kidney injury (AKI) detection is based mainly on serum creatinine, which is considered to delay prompt diagnosis and management, thus increasing substantially patient morbidity and mortality and prolonged hospitalization. Several biomarkers have been evaluated as early prognostic markers of AKI. However, the vast majority of them are still far from being implicated into clinical practice. On the other hand, routine eGFR estimation and proteinuria monitoring have contributed to previous identification of chronic kidney disease (CKD). Hence, more sensitive and specific biomarkers are needed to enable us recognize individuals at increased risk for progression of CKD to end-stage renal disease (ESRD) and occurrence of cardiovascular complications. This review focuses on the most important novel inflammatory biomarkers that have emerged for early prediction, monitoring and management of kidney disease.
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Marinaki S., Skalioti C., Siasos Gerasimos, Papavassiliou G Athanasios, Tousoulis Dimitris and Boletis J.N., The Importance of Novel Inflammatory Biomarkers in Renal Disease, Current Medicinal Chemistry 2015; 22 (23) . https://dx.doi.org/10.2174/0929867322666150415124240
DOI https://dx.doi.org/10.2174/0929867322666150415124240 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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