Abstract
The post-genomic era has completed its first decade. During this time, we have seen an attempt to understand life not just through the study of individual isolated processes, but through the appreciation of the amalgam of complex networks, within which each process can influence others. Greatly benefiting this view has been the study of the epigenome, the set of DNA and histone protein modifications that regulate gene expression and the function of regulatory non-coding RNAs without altering the DNA sequence itself. Indeed, the availability of reference genome assemblies of many species has led to the development of methodologies such as ChIP-Seq and RNA-Seq that have allowed us to define with high resolution the genomic distribution of several epigenetic elements and to better comprehend how they are interconnected for the regulation of gene expression. In the last few years, the use of these methodologies in the cardiovascular field has contributed to our understanding of the importance of epigenetics in heart diseases, giving new input to this area of research. Here, we review recently acquired knowledge on the role of the epigenome in heart failure, and discuss the need of an epigenomics roadmap for cardiovascular disease.
Keywords: Epigenetics, Heart failure, Non-coding RNA, NGS.
Current Genomics
Title:It’s Time for An Epigenomics Roadmap of Heart Failure
Volume: 16 Issue: 4
Author(s): Roberto Papait, Nadia Corrado, Francesca Rusconi, Simone Serio and Michael V.G. Latronico
Affiliation:
Keywords: Epigenetics, Heart failure, Non-coding RNA, NGS.
Abstract: The post-genomic era has completed its first decade. During this time, we have seen an attempt to understand life not just through the study of individual isolated processes, but through the appreciation of the amalgam of complex networks, within which each process can influence others. Greatly benefiting this view has been the study of the epigenome, the set of DNA and histone protein modifications that regulate gene expression and the function of regulatory non-coding RNAs without altering the DNA sequence itself. Indeed, the availability of reference genome assemblies of many species has led to the development of methodologies such as ChIP-Seq and RNA-Seq that have allowed us to define with high resolution the genomic distribution of several epigenetic elements and to better comprehend how they are interconnected for the regulation of gene expression. In the last few years, the use of these methodologies in the cardiovascular field has contributed to our understanding of the importance of epigenetics in heart diseases, giving new input to this area of research. Here, we review recently acquired knowledge on the role of the epigenome in heart failure, and discuss the need of an epigenomics roadmap for cardiovascular disease.
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Cite this article as:
Papait Roberto, Corrado Nadia, Rusconi Francesca, Serio Simone and V.G. Latronico Michael, It’s Time for An Epigenomics Roadmap of Heart Failure, Current Genomics 2015; 16 (4) . https://dx.doi.org/10.2174/1389202916666150505183624
DOI https://dx.doi.org/10.2174/1389202916666150505183624 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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