Chiral Separation of Propranolol Enantiomers by Oxidized Multiwalled Carbon Nanotubes/β-cyclodextrin Impregnated Thin-layer Chromatography

Author(s): Xiao-Qing Chen, Cong-Hao Sun, Fei-Peng Jiao, Jin-Gang Yu, Xin-Yu Jiang

Journal Name: Current Analytical Chemistry

Volume 10 , Issue 2 , 2014

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Extremely good enantioseparation of a kind of commonly used β-blockers, (±)-propranolol, has been achieved on silica gel layers which were impregnated with β-cyclodextrin and oxidized multi-walled carbon nanotubes. Solvent system tert-butenol-acetonitrile (1:1, v/v) successfully resolved the enantiomers of (±)-propranolol. The spots were detected at 254 nm with a UV lamp. The effect of concentration of the mobile phase variation was also studied.

Keywords: Enantioseparation, propranolol, β-cyclodextrin, oxidized multi-walled carbon nanotubes, thin-layer chromatography.

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Article Details

Year: 2014
Page: [267 - 270]
Pages: 4
DOI: 10.2174/15734110113090990028
Price: $65

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