Abstract
The present review details the rational multi-step process followed for the discovery of a family of non-peptide CCK receptor ligands (“dipeptoids”), starting from the structure of the endogenous peptide, CCK8. Emphasis will be made on the N- and C-terminal modifications, on the singular effects of the stereochemical changes and the incorporation of conformational constraints into the structure of “dipeptoids”, and on the modifications directed to improve the pharmacological profile of these compounds to afford valuable clinical candidates.
Keywords: dipeptoids, cholecystokinin, peptidomimetics, rational design
Mini-Reviews in Medicinal Chemistry
Title: “Dipeptoids”: From the Chemical Structure of the Endogenous Peptide to the Design of Peptidomimetics
Volume: 4 Issue: 6
Author(s): Mercedes Martin-Martinez, Rosario Patino-Molina, M. Teresa Garcia-Lopez and Rosario Gonzalez-Muniz
Affiliation:
Keywords: dipeptoids, cholecystokinin, peptidomimetics, rational design
Abstract: The present review details the rational multi-step process followed for the discovery of a family of non-peptide CCK receptor ligands (“dipeptoids”), starting from the structure of the endogenous peptide, CCK8. Emphasis will be made on the N- and C-terminal modifications, on the singular effects of the stereochemical changes and the incorporation of conformational constraints into the structure of “dipeptoids”, and on the modifications directed to improve the pharmacological profile of these compounds to afford valuable clinical candidates.
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Cite this article as:
Martin-Martinez Mercedes, Patino-Molina Rosario, Garcia-Lopez Teresa M. and Gonzalez-Muniz Rosario, “Dipeptoids”: From the Chemical Structure of the Endogenous Peptide to the Design of Peptidomimetics, Mini-Reviews in Medicinal Chemistry 2004; 4 (6) . https://dx.doi.org/10.2174/1389557043403701
DOI https://dx.doi.org/10.2174/1389557043403701 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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