Abstract
An important strategy to circumvent the problem of antimicrobial resistance is to search for new compounds with antimicrobial activity. In this context, aminosterols, which include squalamine-like compounds and ceragenins, have gained interest due to their wide spectrum of antibacterial and antifungal properties. In light of recently reported data, we decided to analyze the mechanism of action of these compounds as well as their antimicrobial properties. Aminosterols are active against both bacterial reference strains and multidrug-resistant antibiotics as they disrupt the integrity of the bacterial membrane. Thus, these compounds could be useful in the development of new topical decontaminants or disinfecting agents.
Keywords: Squalamine, Aminosterol, Antimicrobial agents, Mechanism of action, antimicrobial resistance, ceragenins, aminosterol derivatives, multidrug-resistant, squalamine-like aminosterols (SLAs), sterol, synergistic com-bination, cholic acid, hyodeoxycholic acid, Pseudomonas aeruginosa, Haemophilus influenzae, Escherichia coli, Acinetobacter baumannii, Achromobacter xylosoxidans, Klebsiella pneumoniae, Burkholderia cepacia, Inquilinus limosus, Enterobacter aerogenes, Salmonella typhimurium, polyamino groups, cati-onic peptide antibiotics (CPAs), exopolysaccharides (EPSs), lipopolysaccharide (LPS), transmission electron microscopy (TEM), Plasmodium falciparum, aminosterols, Hemolytic Concentration (MHC), age-related macular degeneration (AMD), polymyxin analogs
Current Medicinal Chemistry
Title: Squalamine as an Example of a New Potent Antimicrobial Agents Class: A Critical Review
Volume: 17 Issue: 32
Author(s): K. Alhanout, J. M. Rolain and J. M. Brunel
Affiliation:
Keywords: Squalamine, Aminosterol, Antimicrobial agents, Mechanism of action, antimicrobial resistance, ceragenins, aminosterol derivatives, multidrug-resistant, squalamine-like aminosterols (SLAs), sterol, synergistic com-bination, cholic acid, hyodeoxycholic acid, Pseudomonas aeruginosa, Haemophilus influenzae, Escherichia coli, Acinetobacter baumannii, Achromobacter xylosoxidans, Klebsiella pneumoniae, Burkholderia cepacia, Inquilinus limosus, Enterobacter aerogenes, Salmonella typhimurium, polyamino groups, cati-onic peptide antibiotics (CPAs), exopolysaccharides (EPSs), lipopolysaccharide (LPS), transmission electron microscopy (TEM), Plasmodium falciparum, aminosterols, Hemolytic Concentration (MHC), age-related macular degeneration (AMD), polymyxin analogs
Abstract: An important strategy to circumvent the problem of antimicrobial resistance is to search for new compounds with antimicrobial activity. In this context, aminosterols, which include squalamine-like compounds and ceragenins, have gained interest due to their wide spectrum of antibacterial and antifungal properties. In light of recently reported data, we decided to analyze the mechanism of action of these compounds as well as their antimicrobial properties. Aminosterols are active against both bacterial reference strains and multidrug-resistant antibiotics as they disrupt the integrity of the bacterial membrane. Thus, these compounds could be useful in the development of new topical decontaminants or disinfecting agents.
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Cite this article as:
Alhanout K., M. Rolain J. and M. Brunel J., Squalamine as an Example of a New Potent Antimicrobial Agents Class: A Critical Review, Current Medicinal Chemistry 2010; 17 (32) . https://dx.doi.org/10.2174/092986710793205417
DOI https://dx.doi.org/10.2174/092986710793205417 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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