Abstract
While significant investments are made across the industry and increasingly also in academia to enhance or build a compound file, the efficient sourcing of compounds from in-house medical chemistry is frequently seen as a challenge. This article introduces the Compound Hub strategy developed at the Novartis Compound Archive. Central Compound Hubs in Basel and Cambridge were combined with web-based ordering of compounds and assays, providing assayready, solubilized samples to labs anywhere in the global research organization. Relieving scientists from time-intensive sample preparation tasks, error rates could be reduced through electronic processing and tracking of compounds/assays and the capture of medicinal chemistry compounds for the compound library could be increased by 75%.
Keywords: Compound management, compound Hub, compound sourcing, ordering software, high throughput screening
Combinatorial Chemistry & High Throughput Screening
Title: Compound Hub: Efficiency Gains Through Innovative Sample Management Processes
Volume: 10 Issue: 4
Author(s): Ulrich Schopfer, Marc R. M. Andreae, Matthieu Hueber, Andreas Saur, Marcel O. Kummer, Michel Girod, Desmond Fox, Thomas Steiner, Maxim Popov and Robert Smith
Affiliation:
Keywords: Compound management, compound Hub, compound sourcing, ordering software, high throughput screening
Abstract: While significant investments are made across the industry and increasingly also in academia to enhance or build a compound file, the efficient sourcing of compounds from in-house medical chemistry is frequently seen as a challenge. This article introduces the Compound Hub strategy developed at the Novartis Compound Archive. Central Compound Hubs in Basel and Cambridge were combined with web-based ordering of compounds and assays, providing assayready, solubilized samples to labs anywhere in the global research organization. Relieving scientists from time-intensive sample preparation tasks, error rates could be reduced through electronic processing and tracking of compounds/assays and the capture of medicinal chemistry compounds for the compound library could be increased by 75%.
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Cite this article as:
Schopfer Ulrich, M. Andreae R. Marc, Hueber Matthieu, Saur Andreas, Kummer O. Marcel, Girod Michel, Fox Desmond, Steiner Thomas, Popov Maxim and Smith Robert, Compound Hub: Efficiency Gains Through Innovative Sample Management Processes, Combinatorial Chemistry & High Throughput Screening 2007; 10 (4) . https://dx.doi.org/10.2174/138620707780636655
DOI https://dx.doi.org/10.2174/138620707780636655 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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