Exploration of Potent Multi-target-directed-ligands as Anti-alzheimer’s Disease Agents: A Moiety Based Review

Title:Exploration of Potent Multi-target-directed-ligands as Anti-alzheimer’s Disease Agents: A Moiety Based Review

Volume: 21 Issue: 20

Author(s): Pankaj Teli, Nusrat Sahiba, Jay Soni, Ayushi Sethiya, Dinesh Kumar Agarwal and Shikha Agarwal*

Affiliation:

• Synthetic Organic Chemistry Laboratory, Department of Chemistry, MLSU, Udaipur, India

Keywords: Multi-target-directed-ligands, alzheimer’s disease, quinoline, chromene, carbazole, cinnamic acids.

Abstract: Abstract: Dementia is a chronic neurodegenerative disease, and a maximum number of the cases are directly related to Alzheimer’s disease. More than 4 million people are living with Alzheimer’s disease-related dementia in India, making it a national crisis. Alzheimer’s disease deteriorates cognitive functions with the passage of time and consists of multi-faceted factors, such as the decline of acetylcholine level, amyloid β-aggregation, tau hyperphosphorylation, oxidative stress, etc. The classical drugs used to date, are focused on only one target and are not serving the cause properly. Hence, the community of scientists is rigorously working on multi-target-directed agents that incorporate two or more active scaffolds in one compound or hybrid of active moieties. This article aims to evaluate novel potential compounds and moieties, such as quinolines, chalcones, coumarins, chromenes, piperazine, carbazoles, cinnamic acids, tacrine hybrids, donepezil hybrids, etc., that have been introduced as multi-target-directed agents in the recent five years.

Cite this article as:

Teli Pankaj , Sahiba Nusrat , Soni Jay , Sethiya Ayushi , Agarwal Kumar Dinesh and Agarwal Shikha *, Exploration of Potent Multi-target-directed-ligands as Anti-alzheimer’s Disease Agents: A Moiety Based Review, Mini-Reviews in Medicinal Chemistry 2021; 21 (20) . https://dx.doi.org/10.2174/1389557521666210304111754