Abstract
Cholesterol, steroid alcohol, was discovered by M.E. Chevreul in 1815. Cholesterol and its derivatives showed a large variety of biological properties such as anticancer activity, anticardiac activity, anti-inflammatory activity, antimicrobial activity, anti-psychotic activity, antioxidant activity, drug-loaded activity, etc. In this mini-review, the advances of structural modification of cholesterol from 2014 to 2020 are summarized. In addition, the bioactivities, mechanisms of action and structureactivity relationships of cholesterol and its related derivatives are also discussed.
Keywords: Cholesterol derivatives, biological activities, structural modification, mechanisms of action, structure-activity relationships.
Mini-Reviews in Medicinal Chemistry
Title:Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships
Volume: 21 Issue: 14
Author(s): Kong Zhang, Tianze Li, Xijie Shan, Rongfei Lu, Shaoyong Zhang and Hui Xu*
Affiliation:
- College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province,China
Keywords: Cholesterol derivatives, biological activities, structural modification, mechanisms of action, structure-activity relationships.
Abstract: Cholesterol, steroid alcohol, was discovered by M.E. Chevreul in 1815. Cholesterol and its derivatives showed a large variety of biological properties such as anticancer activity, anticardiac activity, anti-inflammatory activity, antimicrobial activity, anti-psychotic activity, antioxidant activity, drug-loaded activity, etc. In this mini-review, the advances of structural modification of cholesterol from 2014 to 2020 are summarized. In addition, the bioactivities, mechanisms of action and structureactivity relationships of cholesterol and its related derivatives are also discussed.
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Cite this article as:
Zhang Kong , Li Tianze , Shan Xijie , Lu Rongfei, Zhang Shaoyong and Xu Hui *, Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships, Mini-Reviews in Medicinal Chemistry 2021; 21 (14) . https://dx.doi.org/10.2174/1389557521666210105123320
DOI https://dx.doi.org/10.2174/1389557521666210105123320 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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