Limonene and Perillyl Alcohol Derivatives: Synthesis and Anticancer Activity

Title:Limonene and Perillyl Alcohol Derivatives: Synthesis and Anticancer Activity

Volume: 21 Issue: 14

Author(s): Cesar Emiliano Hoffmann da Silva, Grace Gosmann*Saulo Fernandes de Andrade

Affiliation:

• Laboratory of Phytochemistry and Organic Synthesis (LAFIS), Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre,Brazil

Keywords: Limonene, perillyl alcohol, anticancer, conjugation, hybrid, thiosemicarbazone, carbohydrate.

Abstract: Limonene and perillyl alcohol are natural monoterpenes that have attracted the attention of medicinal chemists due to their promising anticancer activities. Considering this, both compounds were explored as scaffolds to obtain various derivatives with anticancer activity. In this review, the data are organized for the first time, with a focus on the synthetic methods and strategies to obtain the derivatives throughout the period from 2000 to 2020. A brief discussion regarding the structure and activity relationships of the most active derivatives, stereoisomers, and their mechanisms of action is presented. Among the active compounds, a series of limonenes with thiosemicarbazone groups and perillyl alcohol hybrids with glycosides or drugs are illustrated. Taking all of this into account, this review may help researchers develop new promising anticancer candidates based on the structures of limonene and perillyl alcohol.

Cite this article as:

da Silva Hoffmann Cesar Emiliano, Gosmann Grace *, de Andrade Fernandes Saulo , Limonene and Perillyl Alcohol Derivatives: Synthesis and Anticancer Activity, Mini-Reviews in Medicinal Chemistry 2021; 21 (14) . https://dx.doi.org/10.2174/1389557521666210212150504