Generic placeholder image

Current Analytical Chemistry


ISSN (Print): 1573-4110
ISSN (Online): 1875-6727

Research Article

Construction and Studies of Histamine Potentiometric Sensors Based on Molecularly Imprinted Polymer

Author(s): Atsuko Konishi*, Shigehiko Takegami and Tatsuya Kitade

Volume 16, Issue 6, 2020

Page: [788 - 794] Pages: 7

DOI: 10.2174/1573411015666190613165529

Price: $65


Objective: Molecularly Imprinted Polymer (MIP)-modified potentiometric sensors for histamine (HIS) (as denoted as HIS sensor) have been developed.

Methods: The MIPs comprise HIS, Methacrylic Acid (MAA) and ethylene glycol dimethacrylate as the template molecule, functional monomer and cross-linker, respectively. To examine the specificity of the MIP to HIS, the MIP particles were prepared with varying ratios of HIS: MAA and the HIS binding amount toward the MIP particles was determined by UV spectrophotometry. Furthermore, to quantitatively determine the ability of MIP (H2M20) to HIS, a HIS sensor was measured using Ag/AgCl as a reference electrode.

Results: MIP particles having a HIS:MAA of 2 mmol:20 mmol (MIP (H2M20)) had the largest HIS binding amount among the MIP particles prepared. Additionally, MIP (H2M20) displayed a HIS binding amount approximately two times larger than the corresponding non-imprinted polymer (NIP) particles in the absence of template. The HIS sensor potential change increased as a function of HIS concentration and exhibited a near-Nernstian response of −25.7 mV decade−1 over the HIS concentration range of 1×10−5 to 1×10−4 mol L−1 with a limit of detection of 9.6×10−6 mol L−1. From the Nernstian response value, it was observed that the HIS sensor could detect the di-protonated HIS binding to the MIP. Conversely, when comparing at the same HIS concentration, the potential response value of the sensors fabricated using NIP particles were significantly smaller than the values of the corresponding HIS sensor.

Conclusion: The MIP-modified potentiometric sensors can potentially be employed as an analytical method to quantitatively determine various analytes.

Keywords: Calibration curve, functional monomer content, histamine, molecularly imprinted polymer, potentiometric method, sensors.

Graphical Abstract
Schwartz, J-C. Histamine as a transmitter in brain. Life Sci., 1975, 17(4), 503-517.
[] [PMID: 241888]
Hungerford, J.M. Scombroid poisoning: A review. Toxicon, 2010, 56(2), 231-243.
[] [PMID: 20152850]
Yu, X.; Lv, R.; Ma, Z. An impedance array biosensor for detection of multiple antibody-antigen interactions. Analyst (Lond.), 2006, 131(6), 745-750.
[] [PMID: 16732363]
Kim, J.P.; Lee, B.Y.; Hong, S.; Sim, S.J. Ultrasensitive carbon nanotube-based biosensors using antibody-binding fragments. Anal. Biochem., 2008, 381(2), 193-198.
[] [PMID: 18640089]
Shanmugam, S.; Thandavan, K.; Gandhi, S.; Sethuraman, S.; Rayappan, J.B.B.; Krishnan, U.M. Development and evaluation of a highly sensitive rapid response enzymatic nanointerfaced biosensor for detection of putrescine. Analyst (Lond.), 2011, 136(24), 5234-5240.
[] [PMID: 22022700]
Tani, Y.; Tanaka, K.; Yabutani, T. Development of a D-amino acids electrochemical sensor based on immobilization of thermostable D-proline dehydrogenase within agar gel membrane. Anal. Chim. Acta, 2008, 619(2), 215-220.
[] [PMID: 18558115]
Updike, S.J.; Hicks, G.P. The enzyme electrode. Nature, 1967, 214(5092), 986-988.
[] [PMID: 6055414]
Pickup, J.C.; Hussain, F.; Evans, N.D.; Sachedina, N. In vivo glucose monitoring: The clinical reality and the promise. Biosens. Bioelectron., 2005, 20(10), 1897-1902.
[] [PMID: 15741056]
Zhang, Y.; Angelidaki, I. A simple and rapid method for monitoring dissolved oxygen in water with a submersible microbial fuel cell (SBMFC). Biosens. Bioelectron., 2012, 38(1), 189-194.
[] [PMID: 22726635]
Riedel, K.; Renneberg, R.; Kühn, M.; Scheller, F. A fast estimation of biochemical oxygen demand using microbial sensors. Appl. Microbiol. Biotechnol., 1988, 28, 316-318.
Delle, L.E.; Huck, C.; Baecker, M. Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide. Phys. Status Solidi., A Appl. Mater. Sci., 2015, 212, 1327-1334.
Jayaprakasan, A.; Nesakumar, N.; Sethuraman, S.; Krishnan, U.M.; Rayappan, J.B.B. Chemometrics on ceria-polyaniline modified glassy carbon bioelectrode for accurate detection of histamine in fish. J. Comput. Theor. Nanosci., 2015, 12, 1911-1918.
Karim, A.; Wahab, A.W.; Raya, I.; Natsir, H.; Arif, A.R. Utilization of diamine oxidase enzyme from mung bean sprouts (vigna radiata L) for histamine biosensors. J. Phys. Conf. Ser., 2018, 979, 12-14.
Keow, C.M.; Bakar, F.A.; Salleh, A.B.; Heng, L.Y.; Wagiran, R.; Bean, L.S. An amperometric biosensor for the rapid assessment of histamine level in tiger prawn (Penaeus monodon) spoilage. Food Chem., 2007, 105, 1636-1641.
Sekiguchi, Y.; Nishikawa, A.; Makita, H.; Yamamura, A.; Matsumoto, K.; Kiba, N. Flow-through chemiluminescence sensor using immobilized histamine oxidase from Arthrobacter crystallopoietes KAIT-B-007 and peroxidase for selective determination of histamine. Anal. Sci., 2001, 17(10), 1161-1164.
[] [PMID: 11990588]
Bitar, M.; Cayot, P.; Bou-Maroun, E. Molecularly imprinted polymer solid phase extraction of fungicides from wine samples. Anal. Methods, 2014, 6, 6467-6472.
Luo, Q.; Yu, N.; Shi, C.; Wang, X.; Wu, J. Surface plasmon resonance sensor for antibiotics detection based on photo-initiated polymerization molecularly imprinted array. Talanta, 2016, 161, 797-803.
[] [PMID: 27769483]
Urraca, J.L.; Huertas-Pérez, J.F.; Cazorla, G.A.; Gracia-Mora, J.; García-Campaña, A.M.; Moreno-Bondi, M.C. Development of magnetic molecularly imprinted polymers for selective extraction: determination of citrinin in rice samples by liquid chromatography with UV diode array detection. Anal. Bioanal. Chem., 2016, 408(11), 3033-3042.
[] [PMID: 26873195]
Kriz, D.; Mosbach, K. Competitive amperometric morphine sensor based on an agarose immobilised molecularly imprinted polymer. Anal. Chim. Acta, 1995, 300, 71-75.
Kriz, D.; Ramström, O.; Svensson, A.; Mosbach, K. Introducing biomimetic sensors based on molecularly imprinted polymers as recognition elements. Anal. Chem., 1995, 67, 2142-2144.
Kitade, T.; Kitamura, K.; Konishi, T. Potentiometric immunosensor using artificial antibody based on molecularly imprinted polymers. Anal. Chem., 2004, 76(22), 6802-6807.
[] [PMID: 15538807]
Konishi, A.; Takegami, S.; Akatani, S.; Takemoto, R.; Kitade, T. Potentiometric and 1H NMR spectroscopic studies of functional monomer influence on histamine-imprinted polymer-modified potentiometric sensor performance. J. Anal. Bioanal. Tech., 2017, 81, 03-78.
Zhang, Y.; Shimizu, K.D. Chemosensors: Principles, Strategies, and Applications.NJ, USA; John Wiley & Sons, Inc., 2011, pp. 107-20.
Vlatakis, G.; Andersson, L.I.; Müller, R.; Mosbach, K. Drug assay using antibody mimics made by molecular imprinting. Nature, 1993, 361(6413), 645-647.
[] [PMID: 8437624]
Li, Y.; Song, H.; Zhang, L. Supportless electrochemical sensor based on molecularly imprinted polymer modified nanoporous microrod for determination of dopamine at trace level. Biosens. Bioelectron., 2016, 78, 308-314.
[] [PMID: 26630285]
Chen, R.; Deng, Y.; Yang, L.; Wang, J.; Xu, F. Determination of histamine by high-performance liquid chromatography after precolumn derivatization with o-phthalaldehyde-sulfite. J. Chromatogr. Sci., 2016, 54(4), 547-553.
[] [PMID: 26688564]
Hogan, A-M.; Crean, C.; Barrett, U.M.; Guihen, E.; Glennon, J.D. Histamine determination in human urine using sub-2 μm C18 column with fluorescence and mass spectrometric detection. J. Sep. Sci., 2012, 35(9), 1087-1093.
[] [PMID: 22689483]
Švarc-Gajić, J.; Stojanović, Z. Determination of histamine in cheese by chronopotentiometry on a thin film mercury electrode. Food Chem., 2011, 124, 1172-1176..

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy