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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Combinatorial Synthesis of 3,5-Dimethylene Substituted 1,2,4-Triazoles

Author(s): Scott S. Woodard and Kevin D. Jerome

Volume 14, Issue 2, 2011

Page: [132 - 137] Pages: 6

DOI: 10.2174/138620711794474033

Price: $65

Abstract

Combinatorial cyclizations of imidates and hydrazides with methylene linked R groups, generated from the corresponding nitriles and carboxylic acids, respectively, provided a large library of 3,5-dimethylene substituted 1,2,4- trizoles.

Keywords: Cyclizations, combinatorial chemistry, 1,2,4-triazoles, Pinner reaction, hydrazides, imidates, Amberlyst A-21, Methyl imidate HCl, Benzyl imidate, acetonitrile, H NMR, Isovaleroic hydrazide


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