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Cardiovascular & Hematological Agents in Medicinal Chemistry


ISSN (Print): 1871-5257
ISSN (Online): 1875-6182

Research Article

Antidyslipidemic and Antioxidant Activities of Matricaria pubescens (Desf.) Shultz. in Streptozotocin-Induced Diabetic Rats

Author(s): Ayoub Amssayef, Bouchra El Azzaoui, Mohammed Ajebli and Mohamed Eddouks*

Volume 19, Issue 1, 2021

Published on: 06 May, 2020

Page: [62 - 71] Pages: 10

DOI: 10.2174/1871525718666200506100139

Price: $65


Aims: The study aimed to evaluate the antihyperlipidemic and antioxidant activities of Matricaria pubescens.

Background: Matricaria pubescens (Desf.) Shultz belongs to Asteraceae family and it is commonly used traditionally for handling diabetes mellitus.

Objective: The objective of this study was to assess the antioxidant activity of Matricaria pubescens (Desf.) Shultz and its effect on lipid and lipoprotein profile in normal and streptozotocin-induced diabetic rats.

Methods: The effect of repeated (7 days of treatment) oral administration of the aqueous extracts of aerial part of Matricaria pubescens (MPAE) at a dose of 40 mg/kg on lipid and lipoprotein profile was examined in normal and streptozotocin-induced diabetic rats. Furthermore, a preliminary phytochemical screening and the quantification of phenolic, flavonoid and tannin contents as well as the antioxidant activity using two methods (FRAP and ABTS) were carried out.

Results: MPAE demonstrated a potent antidyslipidemic effect in diabetic rats by reducing serum levels of triglycerides, total cholesterol and Low-Density Lipoprotein (LDL). In addition, the results showed that the extract is rich in several phytochemical compounds and revealed an important antioxidant activity.

Conclusion: In summary, this study proved that Matricaria pubescens (Desf.) Shultz. has a favorable effect on diabetic dyslipidemia.

Keywords: Antioxidant, diabetes, lipid, Matricaria pubescens, medicinal plant, streptozotocin.

Graphical Abstract
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