Abstract
Radiolabeled peptides hold promise for diagnosis and therapy of cancer as well as for early monitoring of therapy outcomes, patient stratification, etc. This manuscript focuses on the development of peptides labeled with 18F, 64Cu, 68Ga and other positron-emitting radionuclides for PET imaging. The major techniques for radionuclide incorporation are briefly discussed. Then, examples of positronemitting peptides targeting somatostatin receptors, integrins, gastrin-releasing peptide receptors, vasointestinal peptide receptors, melanocortin 1 receptors and others are reviewed.
Keywords: α-MSH, Bombesin, Octreotide analogs, Peptide receptors, PET, RGD, VIP, SOMATOSTATIN, NEUROENDOCRINE TUMORS, INTEGRIN, ANGIOGENESIS
Anti-Cancer Agents in Medicinal Chemistry
Title:Molecular Imaging of Cancer with Radiolabeled Peptides and PET
Volume: 12 Issue: 5
Author(s): Amy L. Vavere and Raffaella Rossin
Affiliation:
Keywords: α-MSH, Bombesin, Octreotide analogs, Peptide receptors, PET, RGD, VIP, SOMATOSTATIN, NEUROENDOCRINE TUMORS, INTEGRIN, ANGIOGENESIS
Abstract: Radiolabeled peptides hold promise for diagnosis and therapy of cancer as well as for early monitoring of therapy outcomes, patient stratification, etc. This manuscript focuses on the development of peptides labeled with 18F, 64Cu, 68Ga and other positron-emitting radionuclides for PET imaging. The major techniques for radionuclide incorporation are briefly discussed. Then, examples of positronemitting peptides targeting somatostatin receptors, integrins, gastrin-releasing peptide receptors, vasointestinal peptide receptors, melanocortin 1 receptors and others are reviewed.
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Cite this article as:
L. Vavere Amy and Rossin Raffaella, Molecular Imaging of Cancer with Radiolabeled Peptides and PET, Anti-Cancer Agents in Medicinal Chemistry 2012; 12 (5) . https://dx.doi.org/10.2174/187152012800617812
DOI https://dx.doi.org/10.2174/187152012800617812 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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