Abstract
NF-kappaB (NF-κB), the transcription factors of HIV-1, play an important role in triggering HIV transcription. The inhibition of NF-κB activation and their signaling pathway offers a potential anti-HIV therapy strategy. This review reports the mode of action of NF-κB in triggering HIV-1 transcription and the status of the inhibitors.
Keywords: AIDS, HIV-1, NF-κB, transcription, inhibitor, LTR, IκB, IKK
Mini-Reviews in Medicinal Chemistry
Title: NF-κB: The Inducible Factors of HIV-1 Transcription and their Inhibitors
Volume: 9 Issue: 1
Author(s): Yu Mingyan, Liu Xinyong and Erik De Clercq
Affiliation:
Keywords: AIDS, HIV-1, NF-κB, transcription, inhibitor, LTR, IκB, IKK
Abstract: NF-kappaB (NF-κB), the transcription factors of HIV-1, play an important role in triggering HIV transcription. The inhibition of NF-κB activation and their signaling pathway offers a potential anti-HIV therapy strategy. This review reports the mode of action of NF-κB in triggering HIV-1 transcription and the status of the inhibitors.
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Cite this article as:
Mingyan Yu, Xinyong Liu and De Clercq Erik, NF-κB: The Inducible Factors of HIV-1 Transcription and their Inhibitors, Mini-Reviews in Medicinal Chemistry 2009; 9 (1) . https://dx.doi.org/10.2174/138955709787001677
DOI https://dx.doi.org/10.2174/138955709787001677 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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