Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for the treatment of chronic inflammatory diseases suffer from several undesired side effects, the most important being gastrointestinal (GI) irritation and ulceration. The prodrug designing is one of the several strategies used to overcome this drawback. The rationale behind the prodrug concept is to achieve temporary blockade of the free carboxylic group present in the NSAIDs till their systemic absorption. In this paper, a review on the concept of prodrugs designing of NSAIDs to improve their efficacy and reduce the toxicity is being presented.
Keywords: NSAIDs, NO release, amides, esters, inflammation, prodrugs, prostaglandins, ulceration
Mini-Reviews in Medicinal Chemistry
Title: Prodrug Designing of NSAIDs
Volume: 9 Issue: 1
Author(s): Parmeshwari K. Halen, Prashant R. Murumkar, Rajani Giridhar and Mange Ram Yadav
Affiliation:
Keywords: NSAIDs, NO release, amides, esters, inflammation, prodrugs, prostaglandins, ulceration
Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for the treatment of chronic inflammatory diseases suffer from several undesired side effects, the most important being gastrointestinal (GI) irritation and ulceration. The prodrug designing is one of the several strategies used to overcome this drawback. The rationale behind the prodrug concept is to achieve temporary blockade of the free carboxylic group present in the NSAIDs till their systemic absorption. In this paper, a review on the concept of prodrugs designing of NSAIDs to improve their efficacy and reduce the toxicity is being presented.
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Cite this article as:
Halen K. Parmeshwari, Murumkar R. Prashant, Giridhar Rajani and Yadav Ram Mange, Prodrug Designing of NSAIDs, Mini-Reviews in Medicinal Chemistry 2009; 9 (1) . https://dx.doi.org/10.2174/138955709787001695
DOI https://dx.doi.org/10.2174/138955709787001695 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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