Silicon Switches of Marketed Drugs

Author(s): P. K. Pooni, G. A. Showell

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 10 , 2006

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The application of organosilicon chemistry is a strategy to develop best in class drugs applied to targets that have been validated as tractable and drug-able. Silicon switches of known drugs have been synthesised and evaluated in biological assay systems then compared to their marketed all-carbon counterparts. Recent examples include the silicon switches of drugs haloperidol, fexofenadine, bexarotene and venlafaxine.

Keywords: Organosilicon chemistry, silicon switch, marketed drugs, validated targets

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Article Details

Year: 2006
Page: [1169 - 1177]
Pages: 9
DOI: 10.2174/138955706778560120
Price: $65

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