Emerging Therapeutic Targets and Agents for Glioblastoma Migrating Cells

Author(s): Chunhui Di, Austin K. Mattox, Stephen Harward, Cory Adamson

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 10 , Issue 7 , 2010

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Glioblastoma multiforme (GBM) is one of the most common and most aggressive types of primary brain tumors in humans. Even with aggressive surgical resections using state of the art preoperative and intraoperative neuroimaging, along with the most recent techniques in radiotherapy and chemotherapy, the prognosis for GBM patients remains dismal. Survival after diagnosis is about 12-14 months. The tumor cells which already have migrated into normal brain tissue beyond the surgical resection margin account for the inability to effectively treat this tumor. Understanding how to control the migration of GBM cells is paramount to future therapies. In this review, we will focus on the emerging targets and agents which are being exploited to inhibit the migration of glioma cells in GBM.

Keywords: Glioblastoma, tumor cell migration, AJAP, chemotherapy.

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Article Details

Year: 2010
Page: [543 - 555]
Pages: 13
DOI: 10.2174/187152010793498618
Price: $65

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PDF: 30