Abstract
An on-line sample preparation method utilizing a time-programmed autosampler is described for high throughput liquid chromatography / mass spectrometry (LC / MS). This approach is particularly helpful for the LC / MS analysis of samples which require solvents incompatible with HPLC in the sample preparation process. The on-line sample preparation approach minimizes a bottleneck in throughput and improves sample recovery under some circumstances.
Keywords: High Throughput Reversed, Combinatorial Chemistry Libraries, liquid chromatography, Reversed Phase HPLC Columns, dioctyl phthalate, CTC syringe, TentaGel
Combinatorial Chemistry & High Throughput Screening
Title: On-line Sample Preparation for High Throughput Reversed-phase LC / MS Analysis of Combinatorial Chemistry Libraries.
Volume: 4 Issue: 3
Author(s): Liang Tang, William. L. Fitch, Peter Smith, David Tumelty, Kathy Cao and Steven W. Ferla
Affiliation:
Keywords: High Throughput Reversed, Combinatorial Chemistry Libraries, liquid chromatography, Reversed Phase HPLC Columns, dioctyl phthalate, CTC syringe, TentaGel
Abstract: An on-line sample preparation method utilizing a time-programmed autosampler is described for high throughput liquid chromatography / mass spectrometry (LC / MS). This approach is particularly helpful for the LC / MS analysis of samples which require solvents incompatible with HPLC in the sample preparation process. The on-line sample preparation approach minimizes a bottleneck in throughput and improves sample recovery under some circumstances.
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Cite this article as:
Tang Liang, Fitch L. William., Smith Peter, Tumelty David, Cao Kathy and Ferla W. Steven, On-line Sample Preparation for High Throughput Reversed-phase LC / MS Analysis of Combinatorial Chemistry Libraries., Combinatorial Chemistry & High Throughput Screening 2001; 4 (3) . https://dx.doi.org/10.2174/1386207013331110
DOI https://dx.doi.org/10.2174/1386207013331110 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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