An on-line sample preparation method utilizing a time-programmed autosampler is described for high throughput liquid chromatography / mass spectrometry (LC / MS). This approach is particularly helpful for the LC / MS analysis of samples which require solvents incompatible with HPLC in the sample preparation process. The on-line sample preparation approach minimizes a bottleneck in throughput and improves sample recovery under some circumstances.
Keywords: High Throughput Reversed, Combinatorial Chemistry Libraries, liquid chromatography, Reversed Phase HPLC Columns, dioctyl phthalate, CTC syringe, TentaGel
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