Abstract
Glycogen synthase kinase 3 (GSK-3) in the 21st century emerged as one of the most attractive therapeutic target for the development of selective inhibitors as new promising drugs for unmet pathologies including Alzheimers disease, stroke, bipolar disorders, chronic inflammatory processes, cancer and diabetes type II. The full potential of GSK-3 inhibitors is just starting to be realized but the number of candidates in development provided by both academic centres and pharmaceutical companies have increased exponentially in the last two years. This review discloses recent discoveries and developments on peptides and small molecules targeting GSK-3. Focusing attention on this exciting target could thus reap considerable clinical and economic rewards.
Keywords: gsk-3 inhibitors, diabetes type II, neurodegenerative diseases, tau protein
Current Medicinal Chemistry
Title: GSK-3 Inhibitors: Discoveries and Developments
Volume: 11 Issue: 6
Author(s): M. Alonso and A. Martinez
Affiliation:
Keywords: gsk-3 inhibitors, diabetes type II, neurodegenerative diseases, tau protein
Abstract: Glycogen synthase kinase 3 (GSK-3) in the 21st century emerged as one of the most attractive therapeutic target for the development of selective inhibitors as new promising drugs for unmet pathologies including Alzheimers disease, stroke, bipolar disorders, chronic inflammatory processes, cancer and diabetes type II. The full potential of GSK-3 inhibitors is just starting to be realized but the number of candidates in development provided by both academic centres and pharmaceutical companies have increased exponentially in the last two years. This review discloses recent discoveries and developments on peptides and small molecules targeting GSK-3. Focusing attention on this exciting target could thus reap considerable clinical and economic rewards.
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Cite this article as:
Alonso M. and Martinez A., GSK-3 Inhibitors: Discoveries and Developments, Current Medicinal Chemistry 2004; 11 (6) . https://dx.doi.org/10.2174/0929867043455738
DOI https://dx.doi.org/10.2174/0929867043455738 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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