Phyto-Facilitated Bimetallic ZnFe2O4 Nanoparticles via Boswelliacarteri: Synthesis, Characterization, and Anti-Cancer Activity

Author(s): Amer Imraish*, Afnan Al-Hunaiti, Tuqa Abu-Thiab, Abed Al-Qader Ibrahim, Eman Hwaitat, Asma Omar

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 21 , Issue 13 , 2021


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Abstract:

Background: The growing dissatisfaction with the available traditional chemotherapeutic agents has enhanced the need to develop new methods for obtaining materials with more effective and safe anti-cancer properties. Over the past few years, the usage of metallic nanoparticles has been a target for researchers of different scientific and commercial fields due to their tiny sizes, environment-friendly properties, and a wide range of applications. To overcome the obstacles of traditional physical and chemical methods for the synthesis of such nanoparticles, a new, less expensive, and eco-friendly method has been adopted using natural existing organisms as a reducing agent to mediate the synthesis of the desired metallic nanoparticles from their precursors, a process called green biosynthesis of nanoparticles.

Objective: In the present study, zinc-iron bimetallic nanoparticles (ZnFe2O4) were synthesized via an aqueous extract of BoswelliaCarteri resin mixed with zinc acetate and iron chloride precursors, and they were tested for their anticancer activity.

Methods: Various analytic methods were applied for the characterization of the phyto synthesized ZnFe2O4, and they were tested for their anticancer activity against MDA-MB-231, K562, MCF-7 cancer cell lines, and normal fibroblasts.

Results: Our results demonstrate the synthesis of cubic structured bimetallic nanoparticles ZnFe2O4 with an average diameter of 10.54 nm. MTT cytotoxicity assay demonstrates that our phyto-synthesized ZnFe2O4 nanoparticles exhibited a selective and potent anticancer activity against K562 and MDA-MB-231 cell lines with IC50 values 4.53 μM and 4.19 μM, respectively.

Conclusion: In conclusion, our biosynthesized ZnFe2O4 nanoparticles show a promising, environmentally friendly, and low coast chemotherapeutic approach against selective cancers with a predicted low adverse side effect toward normal cells. Further, in vivo, advanced animal research should be done to execute their applicability in living organisms.

Keywords: Boswelliacarteri, cancer, green-biosynthesis, K562, nanoparticles, ZnFe2O4.

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Article Details

VOLUME: 21
ISSUE: 13
Year: 2021
Page: [1767 - 1772]
Pages: 6
DOI: 10.2174/1871520621666201218114040
Price: $95

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