Background: Novel coronavirus SARS-CoV-2 is responsible of COVID-19 pandemic. It was first reported in
Wuhan, China in December, 2019 and despite the tremendous efforts to control the disease, it has now spread almost all
over the world.The interaction of SARS-CoV-2spike protein and its acceptor protein ACE2 is an important issue in determining viralhost range and cross-species infection, while the binding capacity of spike protein toACE2 of different species
Objective: The present study has been conducted to determine the susceptibility of livestock, poultry and pets to SARSCoV-2.
Methods: We evaluated the receptor-utilizing capability of ACE2sfrom various species by sequence alignment,phylogenetic
clustering and protein-ligand interaction studies with the currently knownACE2s utilized by SARS-CoV-2.
Result:In-silico study predicted that SARS-CoV-2 tends to utilize ACE2s ofvarious animal species with varied possible interactions and theprobability ofthe receptor utilization will be greater in horse and poor in chicken followed by ruminants.
Conclusion: Present studypredicted that SARS-CoV-2 tends to utilize ACE2s ofvarious livestock and poultry species with
greater probability in equine and poor in chicken. Study may provide important insights into the animal models for SARSCoV-2 and animal management for COVID-19 control.