Effects of Gentiana lutea Root on Vascular Diseases

Author(s): Gordana Joksic, Djordje Radak, Emina Sudar-Milovanovic, Milan Obradovic, Jelena Radovanovic, Esma R. Isenovic*

Journal Name: Current Vascular Pharmacology

Volume 19 , Issue 4 , 2021


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Abstract:

Background: Gentiana lutea (GL), commonly known as yellow gentian, bitter root, and bitterwort, belongs to family Gentianaceae. GL belongs to genus Gentiana, which is a rich natural source of iridoids, secoiridoids, xantones, flavonoids, triterpenoids, and carbohydrates. Medicinal plants from Gentiana species have anti-oxidant, anti-inflammatory, anti-mitogenic, anti-proliferative, and lipidlowering effects, as well as a cardioprotective, hypotensive, vasodilator and anti-platelet activities.

Objective: We reviewed the recent literature related to the effects of Gentiana species, and their active components on vascular diseases.

Methods: Data used for this review were obtained by searching the electronic database [PUBMED/ MEDLINE 1973 - February 2020]. The primary data search terms of interest were: Gentiana lutea, Gentienacea family, phytochemistry, vascular diseases, treatment of vascular diseases, antioxidant, anti-inflammatory, anti-atherogenic.

Conclusion: Gentiana species and their constituents affect many different factors related to vascular disease development and progression. Therefore, Gentiana-based therapeutics represent potentially useful drugs for the management of vascular diseases.

Keywords: Gentiana lutea, Gentienacea family, phytochemistry, vascular diseases, treatment of vascular diseases, antioxidant, anti-inflammatory, anti-atherogenic.

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Article Details

VOLUME: 19
ISSUE: 4
Year: 2021
Published on: 28 May, 2020
Page: [359 - 369]
Pages: 11
DOI: 10.2174/1570161118666200529111314
Price: $65

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