Background: Gentiana lutea (GL), commonly known as yellow gentian, bitter root, and bitterwort,
belongs to family Gentianaceae. GL belongs to genus Gentiana, which is a rich natural source
of iridoids, secoiridoids, xantones, flavonoids, triterpenoids, and carbohydrates. Medicinal plants from
Gentiana species have anti-oxidant, anti-inflammatory, anti-mitogenic, anti-proliferative, and lipidlowering
effects, as well as a cardioprotective, hypotensive, vasodilator and anti-platelet activities.
Objective: We reviewed the recent literature related to the effects of Gentiana species, and their active
components on vascular diseases.
Methods: Data used for this review were obtained by searching the electronic database [PUBMED/
MEDLINE 1973 - February 2020]. The primary data search terms of interest were: Gentiana
lutea, Gentienacea family, phytochemistry, vascular diseases, treatment of vascular diseases, antioxidant,
Conclusion: Gentiana species and their constituents affect many different factors related to vascular
disease development and progression. Therefore, Gentiana-based therapeutics represent potentially useful
drugs for the management of vascular diseases.