Abstract
Plant secondary metabolites are considered as a valuable source to identify promising lead compounds for developing novel drugs. Platycodin D is regarded as one of the major bioactive compounds in medicinal plant Platycodon grandiflorum, which attracts researchers to study its therapeutic effect recently. This paper reviews the latest research of biological and pharmacological activities of platycodin D. In vitro and in vivo experimental evidences have revealed that platycodin D demonstrates multiple pharmacological properties including anti-oxidative, anti-inflammatory, anticancer, antiobesity and hepatoprotective effects. The underlying mechanisms of multiple therapeutic functions of platycodin D are very likely associated with its anti-inflammatory and antioxidant nature, whereas low bioavailability should be considered in drug development.
Keywords: Platycodin D, Platycodon grandiflorum, antioxidant, anti-inflammation, anticancer, anti-obesity, hepatoprotection.
Mini-Reviews in Organic Chemistry
Title:Multi-target Pharmacological Effects of Platycodin D
Volume: 14 Issue: 4
Author(s): Zhong-rong Zhang and Chun Wai Chan*
Affiliation:
- School of Chinese Medicine, Li Wai Chun Building, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong,China
Keywords: Platycodin D, Platycodon grandiflorum, antioxidant, anti-inflammation, anticancer, anti-obesity, hepatoprotection.
Abstract: Plant secondary metabolites are considered as a valuable source to identify promising lead compounds for developing novel drugs. Platycodin D is regarded as one of the major bioactive compounds in medicinal plant Platycodon grandiflorum, which attracts researchers to study its therapeutic effect recently. This paper reviews the latest research of biological and pharmacological activities of platycodin D. In vitro and in vivo experimental evidences have revealed that platycodin D demonstrates multiple pharmacological properties including anti-oxidative, anti-inflammatory, anticancer, antiobesity and hepatoprotective effects. The underlying mechanisms of multiple therapeutic functions of platycodin D are very likely associated with its anti-inflammatory and antioxidant nature, whereas low bioavailability should be considered in drug development.
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Cite this article as:
Zhang Zhong-rong and Chan Wai Chun *, Multi-target Pharmacological Effects of Platycodin D, Mini-Reviews in Organic Chemistry 2017; 14 (4) . https://dx.doi.org/10.2174/1570193X14666170519154614
DOI https://dx.doi.org/10.2174/1570193X14666170519154614 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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