Abstract
In cardiology and oncology, early disease detection produces better patient outcomes. Imaging approaches, particularly Magnetic Resonance Imaging (MRI), are attractive for screening large, mostly disease-free populations because they are noninvasive and produce high-resolution anatomical/morphological images from disease sites. Biochemically targeted nanoparticulate contrast agents (ultrasmall superparamagnetic iron oxide particles called USPIOs, superparamagnetic iron oxide nanoparticles called SPIONs, cross-linked iron oxides called CLIOs, Gadolinium chelates, and other superparamagnetic or paramagnetic particles) can be administered parenterally to define lesional biochemical/cellular composition, in addition to giving excellent definition of morphological features. Such targeted contrast agents can be considered modular nanobiological devices containing, at minimum, a contrast module and a targeting moiety. Here we review synthesis, surface chemistry and physics of superparamagnetic iron oxide MRI contrast agents (USPIOs and SPIONs) and results to date from the use of biochemically targeted and untargeted iron oxide MRI contrast agents in vivo, in vitro and ex vivo in vascular disease, and to a lesser extent, in oncology applications. We discuss design parameters critical to in vivo use of targeted contrast particles, including parameters influencing particle biodistribution/pharmacokinetics and immunogenicity. We discuss the increasing sophistication of theranostic contrast agents that provide other physiological services concurrent with their MRI function.
Keywords: Atherosclerosis, superparamagnetic nanoparticles, MRI, molecular imaging, vulnerable plaque, contrast agents
Current Nanoscience
Title: Nanoparticulate Iron Oxide Contrast Agents for Untargeted and Targeted Cardiovascular Magnetic Resonance Imaging
Volume: 5 Issue: 1
Author(s): A. Jasper Nijdam, Theodore R. Nicholson III, John P. Shapiro, Bryan R. Smith, Johannes T. Heverhagen, Petra Schmalbrock, Michael V. Knopp, Andrew Kebbel, David Wang and Stephen C. Lee
Affiliation:
Keywords: Atherosclerosis, superparamagnetic nanoparticles, MRI, molecular imaging, vulnerable plaque, contrast agents
Abstract: In cardiology and oncology, early disease detection produces better patient outcomes. Imaging approaches, particularly Magnetic Resonance Imaging (MRI), are attractive for screening large, mostly disease-free populations because they are noninvasive and produce high-resolution anatomical/morphological images from disease sites. Biochemically targeted nanoparticulate contrast agents (ultrasmall superparamagnetic iron oxide particles called USPIOs, superparamagnetic iron oxide nanoparticles called SPIONs, cross-linked iron oxides called CLIOs, Gadolinium chelates, and other superparamagnetic or paramagnetic particles) can be administered parenterally to define lesional biochemical/cellular composition, in addition to giving excellent definition of morphological features. Such targeted contrast agents can be considered modular nanobiological devices containing, at minimum, a contrast module and a targeting moiety. Here we review synthesis, surface chemistry and physics of superparamagnetic iron oxide MRI contrast agents (USPIOs and SPIONs) and results to date from the use of biochemically targeted and untargeted iron oxide MRI contrast agents in vivo, in vitro and ex vivo in vascular disease, and to a lesser extent, in oncology applications. We discuss design parameters critical to in vivo use of targeted contrast particles, including parameters influencing particle biodistribution/pharmacokinetics and immunogenicity. We discuss the increasing sophistication of theranostic contrast agents that provide other physiological services concurrent with their MRI function.
Export Options
About this article
Cite this article as:
Nijdam Jasper A., Nicholson III R. Theodore, Shapiro P. John, Smith R. Bryan, Heverhagen T. Johannes, Schmalbrock Petra, Knopp V. Michael, Kebbel Andrew, Wang David and Lee C. Stephen, Nanoparticulate Iron Oxide Contrast Agents for Untargeted and Targeted Cardiovascular Magnetic Resonance Imaging, Current Nanoscience 2009; 5 (1) . https://dx.doi.org/10.2174/157341309787314601
DOI https://dx.doi.org/10.2174/157341309787314601 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Effect of Levothyroxine in Comparison with Placebo on Serum Osteocalcin
Levels in Patients with Subclinical Hypothyroidism
Current Drug Safety An Insight into the Recent Diabetes Trials: What is the Best Approach to Prevent Macrovascular and Microvascular Complications?
Current Diabetes Reviews Pegaptanib Sodium for the Treatment of Proliferative Diabetic Retinopathy and Diabetic Macular Edema
Current Diabetes Reviews Inhibitors of Serine Proteinases from Blood Coagulation Cascade - View on Current Developments
Mini-Reviews in Medicinal Chemistry Treating Arterial Stiffness in Young and Elderly Patients with the Metabolic Syndrome
Current Pharmaceutical Design Dissections of the Thoracic Aorta and Evolving Endovascular Strategies
Current Hypertension Reviews Transforming Growth Factor-β, Cell Signaling and Cardiovascular Disorders
Current Vascular Pharmacology Vascular Contribution to Alzheimer Disease: Predictors of Rapid Progression
CNS & Neurological Disorders - Drug Targets Pathophysiological Role of Proteasome-Dependent Proteolytic Pathway in Endothelin-1-Related Cardiovascular Diseases
Current Vascular Pharmacology Nutrigenomic Analysis of Diet-Gene Interactions on Functional Supplements for Weight Management
Current Genomics Inhibition of Mitogen-Activated Protein Kinases (MAPKs) as a Strategy to Prevent Intimal Hyperplasia Following Cardiovascular Interventions
Vascular Disease Prevention (Discontinued) Atherosclerotic Plaque Stabilization - Potential Role for Immunomodulatory Therapy
Vascular Disease Prevention (Discontinued) Placental Hypoxia Developed During Preeclampsia Induces Telocytes Apoptosis in Chorionic Villi Affecting The Maternal-Fetus Metabolic Exchange
Current Stem Cell Research & Therapy Emerging Therapy Options in Heparin-Induced Thrombocytopenia
Cardiovascular & Hematological Agents in Medicinal Chemistry Arterial Dilatation-Related Diseases: The Prerequisite Condition of Arterial Elastic Tissue Damage and Endovascular Treatment
Recent Patents on Medical Imaging Vascular Oxidative Stress: A Key Factor in the Development of Hypertension Associated with Ethanol Consumption
Current Hypertension Reviews Matrix Metalloproteinases and Vulnerable Atheromatous Plaque
Current Topics in Medicinal Chemistry Angiogenesis Inhibitors: Current & Future Directions
Current Pharmaceutical Design Water Soluble Vitamins and their Role in Diabetes and its Complications
Current Diabetes Reviews Recent Developments in Thrombin-Activatable Fibrinolysis Inhibitor Research
Mini-Reviews in Medicinal Chemistry