Every year more than 12,000 people in US alone suffer from spinal cord injury. However, complete
recovery of physical function is difficult due to multiple factors involved in disease progression. Currently
available therapeutic regimens do not address all the factors concerned with the disease progression.
The present review focuses mainly on the role of immune cells in progression of spinal cord injury and the
drugs that target these immune cells. Literature search shows that inflammatory reactions and subsequent
reactions that follow direct injury to spinal cord are sometimes responsible for the severity of the disease. Therefore, for
design of proper treatment regimen a deep understanding in this area is required. Understanding the pathophysiology will
help in creating delivery system that can target multiple factors involved in progression of spinal cord injury. A combination
of various treatment strategies is required to reduce the disability in patients with spinal cord injury.
Keywords: Autoimmunity, immune system, inflammation, natural compounds, spinal cord injury.
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