Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs. Anti-obesity Drug Discovery and Development is focused on this very important area of healthcare research. Fifteen well written reviews make this special volume an excellent compilation of recent developments in anti-obesity treatment. The reviews cover a variety of topics including the development of specific, safe and effective receptor antagonists, the role of epithelial endocrine cells and post operative treatment strategies. This book should be useful to clinicians and medicinal chemists involved in ant-obesity research and therapy.

This authoritative reference provides update information on the fundamental aspects and applications of biomaterials and biomedical sciences. It includes nickel-titanium alloys with superelasticity and shape memory effect, bioactive bone cement for orthopedic applications, and new research trends in polymer nanocomposites. This Ebook also describes the response of cells to ionizing radiation such as DNA damage responses in zebrafish. With chapters contributed by eminent scientists in the field of biophysics, biomaterials and biomedical engineering, this is a useful reference for graduate students, researchers and professionals in biomedical sciences and technologies.

The first volume of this Ebook series brings together the most recent advances from leading experts in the burgeoning field of biotechnology. This comprehensive text adopts a multidisciplinary approach and covers agricultural biotechnology, industrial and environmental biotechnology, pharmaceutical sciences and drug developments from plant sources, biochemical and molecular studies on gene expression, forestry, genetic engineering, gene delivery approaches, plant tissue culture and biochemical techniques/methods/protocols involved in different areas of plant biotechnology. This Ebook should prove to be a valuable resource for plant biotechnologists, plant biologists, biochemists, molecular biologists, pharmacologists, and pharmacists; agronomists, plant breeders, and geneticists; ethnobotanists, ecologists, and conservationists; medical practitioners and nutritionists; research investigators in industry, federal laboratories, and universities; and students and teachers in the biological and biomedical sciences at undergraduate and postgraduate levels.

Angiogenesis plays rate limiting roles in tumor growth and invasion. Angiogenesis inhibition has been proposed as a general strategy to fight against cancers. This book covers different therapeutic targets for angiogenesis interventions with emphasis on clinical development of antiangiogenic drugs that target antiangiogenic cascade in different forms of cancers like breast cancer, multiple myeloma, renal carcinoma, gastrointestinal, prostate and lung cancer. Surrogate predictive markers of antiangiogenic therapy in novel preclinical models recapitulating tumor microenvironment together with genomic studies are special features of this book. Gene therapy approaches with emphasis on viral vectors have been explored in preclinical model with direct and indirect angiogenesis inhibitors. Recent advances in clinical application with antiangiogenic therapy resulted in encouraging clinical results are also detailed. It includes chapters that bridge the gap between basic science and clinical application of current knowledge of cancer. Different chapters are contributed by distinguished scientists and clinicians around the world making it an important addition to the bookshelves of clinicians, academics, researchers, students and institutions.

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Anti-angiogenesis Drug Discovery and Development provides an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

“Frontiers in Anti-Cancer Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The eBook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Cancer drug design and discovery. Each volume is devoted to the major advances in Anti-Cancer drug design and discovery. The eBook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

“Frontiers in Cardiovascular Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in Cardiovascular drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The eBook series should prove to be of interest to all pharmaceutical scientists involved in research in cardiovascular drug design and discovery. Each volume is devoted to the major advances in cardiovascular drug design and discovery. The eBook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

“Frontiers in CNS Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in Central Nervous System (CNS) drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The eBook series should prove to be of interest to all pharmaceutical scientists involved in research in CNS drug design and discovery. Each volume is devoted to the major advances in CNS drug design and discovery. The eBook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The book series should prove to be of interest to all the pharmaceutical scientists involved in research in drug design and discovery. Each volume is devoted to the major advances in drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The book series is available in print, online and CD editions.

Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The book series should prove to be of interest to all the pharmaceutical scientists involved in research in drug design and discovery. Each volume is devoted to the major advances in drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The book series is available in print, online and CD editions.