Abstract
Glutamate receptors are implicated in many actions in the central nervous system, as an excitatory amino acid, and one of the more relevant is its role in excitotoxicity. Apart from this, it also has a role as pronociceptive agent, so that antagonizing its actions could be of interest for developing new analgesic agents. Furthermore, between the analgesics agents, it is of outstanding interest the fact that there is no specific therapy against the neuropathic pain, and glutamate receptor subunits have elicited as new potential targets for this disturbance.
Keywords: neuropathic pain, allodynia, hyperalgesia, ampa, ionotropic receptor
Mini-Reviews in Medicinal Chemistry
Title: AMPA Glutamate Receptors and Neuropathic Pain
Volume: 3 Issue: 7
Author(s): Susana Morales-Alcelay, Laura Rubio and Ana Martinez
Affiliation:
Keywords: neuropathic pain, allodynia, hyperalgesia, ampa, ionotropic receptor
Abstract: Glutamate receptors are implicated in many actions in the central nervous system, as an excitatory amino acid, and one of the more relevant is its role in excitotoxicity. Apart from this, it also has a role as pronociceptive agent, so that antagonizing its actions could be of interest for developing new analgesic agents. Furthermore, between the analgesics agents, it is of outstanding interest the fact that there is no specific therapy against the neuropathic pain, and glutamate receptor subunits have elicited as new potential targets for this disturbance.
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Cite this article as:
Morales-Alcelay Susana, Rubio Laura and Martinez Ana, AMPA Glutamate Receptors and Neuropathic Pain, Mini-Reviews in Medicinal Chemistry 2003; 3 (7) . https://dx.doi.org/10.2174/1389557033487719
DOI https://dx.doi.org/10.2174/1389557033487719 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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