Exploiting Endogenous Cellular Process to Generate Quinone Methides In Vivo

Author(s): Sheng Cao, Xiaohua Peng

Journal Name: Current Organic Chemistry

Volume 18 , Issue 1 , 2014

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Quinone methides (QMs) are naturally occurring reactive intermediates which play important roles in organic syntheses as well as in a large number of chemical andbiological processes. QMs are also believed to be responsible for the ultimate cytotoxicity of many antitumor drugs, antibiotics, and DNA alkylators through enzyme inhibition or DNA alkylation. Many different chemical methods have been developed to synthesize QMs and their derivatives. This review highlights generation of QMs by exploiting cellular process and their biological applications.

Keywords: Quinone methides, in vivo generation, enzymatic oxidation, phenols, enzymatic reduction, quinones, ROS induction, arylboronates and arylboronic acids.

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Article Details

Year: 2014
Page: [70 - 85]
Pages: 16
DOI: 10.2174/138527281801140121123221

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PDF: 41