Abstract
Quinone methides (QMs) are naturally occurring reactive intermediates which play important roles in organic syntheses as well as in a large number of chemical andbiological processes. QMs are also believed to be responsible for the ultimate cytotoxicity of many antitumor drugs, antibiotics, and DNA alkylators through enzyme inhibition or DNA alkylation. Many different chemical methods have been developed to synthesize QMs and their derivatives. This review highlights generation of QMs by exploiting cellular process and their biological applications.
Keywords: Quinone methides, in vivo generation, enzymatic oxidation, phenols, enzymatic reduction, quinones, ROS induction, arylboronates and arylboronic acids.
Current Organic Chemistry
Title:Exploiting Endogenous Cellular Process to Generate Quinone Methides In Vivo
Volume: 18 Issue: 1
Author(s): Sheng Cao and Xiaohua Peng
Affiliation:
Keywords: Quinone methides, in vivo generation, enzymatic oxidation, phenols, enzymatic reduction, quinones, ROS induction, arylboronates and arylboronic acids.
Abstract: Quinone methides (QMs) are naturally occurring reactive intermediates which play important roles in organic syntheses as well as in a large number of chemical andbiological processes. QMs are also believed to be responsible for the ultimate cytotoxicity of many antitumor drugs, antibiotics, and DNA alkylators through enzyme inhibition or DNA alkylation. Many different chemical methods have been developed to synthesize QMs and their derivatives. This review highlights generation of QMs by exploiting cellular process and their biological applications.
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Cite this article as:
Cao Sheng and Peng Xiaohua, Exploiting Endogenous Cellular Process to Generate Quinone Methides In Vivo, Current Organic Chemistry 2014; 18 (1) . https://dx.doi.org/10.2174/138527281801140121123221
DOI https://dx.doi.org/10.2174/138527281801140121123221 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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