MicroRNA (miRNA) is an important type of non-coding RNAs with both physiological and pathological functions
in human beings. Aberrant expression of miRNAs has been found in tumor tissues and the expression profile of certain
groups of miRNAs is now emerging as bio-marker for cancer. It has been confirmed that miRNAs can exert oncogenic
or tumor-suppressive functions through repressing the expression of their target genes which play different roles in
tumorigenesis. The identification of oncogenic or tumor-suppressive miRNAs allows potential applications of these miRNAs
as targets for cancer chemotherapy. In this review, we summarized the well-known cancer-related miRNAs reported
in recent years and the roles they played in tumorigenesis and progression by targeting specific genes. Strategies developed
to modulate the function or expression of the dysregulated miRNAs are also reviewed with recent examples illustrating
their potential applications in cancer chemotherapy.
Keywords: MicroRNA, oncogenic, tumor-suppressive, up-regulation, down-regulation, tumorigenesis, cancer chemotherapy.
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Published on: 31 July, 2013
Page: [3574 - 3581]