Abstract
An efficient synthesis of thiazoles is described via an one-pot reaction between acid chlorides, ammonium thiocyanate tetramethylguanidine and α-bromocarbonyl compounds under solvent-free conditions without using any catalyst. The method offers several advantages including high yields of products and an easy work-up procedure at room temperature in excellent yield.
Keywords: Arylisothiocyanates, one-pot reactions, tetramethylguanidine, thiazoles.
Combinatorial Chemistry & High Throughput Screening
Title:Solvent-Free Synthesis of Functionalized Thiazoles Using Multicomponent Reaction of Isothiocyanates
Volume: 16 Issue: 9
Author(s): Seyyedeh Zahra Sayyed-Alangi, Zinatossadat Hossaini, Faramarz Rostami-Charati and Hadi Sajjadi-Ghotabadi
Affiliation:
Keywords: Arylisothiocyanates, one-pot reactions, tetramethylguanidine, thiazoles.
Abstract: An efficient synthesis of thiazoles is described via an one-pot reaction between acid chlorides, ammonium thiocyanate tetramethylguanidine and α-bromocarbonyl compounds under solvent-free conditions without using any catalyst. The method offers several advantages including high yields of products and an easy work-up procedure at room temperature in excellent yield.
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Cite this article as:
Sayyed-Alangi Zahra Seyyedeh, Hossaini Zinatossadat, Rostami-Charati Faramarz and Sajjadi-Ghotabadi Hadi, Solvent-Free Synthesis of Functionalized Thiazoles Using Multicomponent Reaction of Isothiocyanates, Combinatorial Chemistry & High Throughput Screening 2013; 16 (9) . https://dx.doi.org/10.2174/13862073113169990036
DOI https://dx.doi.org/10.2174/13862073113169990036 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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