Solvent-Free Synthesis of Functionalized Thiazoles Using Multicomponent Reaction of Isothiocyanates

Author(s): Seyyedeh Zahra Sayyed-Alangi, Zinatossadat Hossaini, Faramarz Rostami-Charati, Hadi Sajjadi-Ghotabadi

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 16 , Issue 9 , 2013


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Abstract:

An efficient synthesis of thiazoles is described via an one-pot reaction between acid chlorides, ammonium thiocyanate tetramethylguanidine and α-bromocarbonyl compounds under solvent-free conditions without using any catalyst. The method offers several advantages including high yields of products and an easy work-up procedure at room temperature in excellent yield.

Keywords: Arylisothiocyanates, one-pot reactions, tetramethylguanidine, thiazoles.

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Article Details

VOLUME: 16
ISSUE: 9
Year: 2013
Published on: 31 August, 2013
Page: [758 - 761]
Pages: 4
DOI: 10.2174/13862073113169990036
Price: $65

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