Title:Review on Chemogenomics Approach: Interpreting Antagonist Activity of Secreted Frizzled-Related Protein 1 in Glaucoma Disease with In-Silico Docking
VOLUME: 12 ISSUE: 16
Author(s):Kirtan Dave and Hetalkumar Panchal
Affiliation:G.H. Patel P.G. Dept. of Computer Science and Technology. Sardar Patel University, Vallabh Vidyanagar; Gujarat, India.
Keywords:Chemogenomics, sFRP1, drug design, conserved rich domain (CRD), Wnt signalling pathway, docking, Computer-aided drug discovery, Wnt signalling pathway
Abstract:Computer-aided drug discovery is a growing frontier in science. It covers different sub areas like chemoinformatics
and chemogenomics. Chemogenomics is one of the emerging inter-disciplinary approaches in drug discovery,
which combines conventional ligand based approach with biological information of drug targets. The main goal of this
review is to check effective application of chemogenomics in understanding interactions between all possible ligands and
their potential drug targets at molecular level. Recent studies revealed that increased expression of sFRP1an inhibitor of
Wnt signalling pathway, seems to be responsible for Elevated Intracellular Pressure (IOP) in glaucoma patients.
Glaucoma is a worldwide spread disease. Here, secreted frizzled-related protein-1 (sFRP1) has been used as a target
protein. An important role of sFRP1, an antagonist of Wnt signalling pathway, has been found in regulating IOP. Wnt3a
ligand protein and a natural compound from marine source Mycaperoxide H - have been used as ligands. In-silico docking
of these ligands with sFRP family implies answers to many intricate queries in drug development field. Using above
mentioned ligand-protein model in this study, application of chemogenomics has tried to explore the interaction of active
site of proteins with the novel ligands. Henceforth, the present review will focus on predictive in-silico chemogenomic
approaches with computer aided drug design could be used in drug design domain in identifying new targets in various
diseases, in time and cost effective manner.
