Abstract
Many findings have evidenced antioxidant properties of hyaluronan, both in vitro and in vivo, by means of which it can scavenge free radicals and exert its effect on pathologies. The aim of this review is to summarize the available data on the features and clinical profile of hyaluronan, with regard in particular to its antioxidant capacity and to its related physico-chemical properties. Additionally, hyaluronan and its derivatives are examined, with the focus on their therapeutic uses, protection against cellular damage, and their role as inflammatory mediators. Finally, therapies associated to the antioxidant effect of hyaluronan are discussed.
Keywords: Hyaluronan, antioxidants, reactive oxygen species, oxidative damage, inflammation, therapeutic use
Mini-Reviews in Medicinal Chemistry
Title: Antioxidant Profile of Hyaluronan: Physico-Chemical Features and its Role in Pathologies
Volume: 9 Issue: 13
Author(s): G. Mendoza, J. G. Prieto, R. Real, M. Perez, G. Merino and A. I. Alvarez
Affiliation:
Keywords: Hyaluronan, antioxidants, reactive oxygen species, oxidative damage, inflammation, therapeutic use
Abstract: Many findings have evidenced antioxidant properties of hyaluronan, both in vitro and in vivo, by means of which it can scavenge free radicals and exert its effect on pathologies. The aim of this review is to summarize the available data on the features and clinical profile of hyaluronan, with regard in particular to its antioxidant capacity and to its related physico-chemical properties. Additionally, hyaluronan and its derivatives are examined, with the focus on their therapeutic uses, protection against cellular damage, and their role as inflammatory mediators. Finally, therapies associated to the antioxidant effect of hyaluronan are discussed.
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Mendoza G., Prieto G. J., Real R., Perez M., Merino G. and Alvarez I. A., Antioxidant Profile of Hyaluronan: Physico-Chemical Features and its Role in Pathologies, Mini-Reviews in Medicinal Chemistry 2009; 9 (13) . https://dx.doi.org/10.2174/138955709790361494
DOI https://dx.doi.org/10.2174/138955709790361494 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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