Abstract
2-Phenyl-3-hydroxy-4(1H)-quinolinones can be considered as aza-analogues of flavones, compounds which are known for the wide-range of their biological activity. These quinolinones were studied as inhibitors of topoisomerase, gyrase and IMPDH. They were tested for anticancer activity in-vitro and were also shown to possess immunosuppressive properties. This review is the first summarizing the synthesis and activity of the mentioned quinolinones.
Keywords: Quinolinones, anticancer activity, antibacterial activity, inhibition
Mini-Reviews in Medicinal Chemistry
Title: 3-Hydroxy-2-phenyl-4(1H)-quinolinones as Promising Biologically Active Compounds
Volume: 9 Issue: 6
Author(s): P. Hradil, J. Hlavac, M. Soural, M. Hajduch, M. Kolar and R. Vecerova
Affiliation:
Keywords: Quinolinones, anticancer activity, antibacterial activity, inhibition
Abstract: 2-Phenyl-3-hydroxy-4(1H)-quinolinones can be considered as aza-analogues of flavones, compounds which are known for the wide-range of their biological activity. These quinolinones were studied as inhibitors of topoisomerase, gyrase and IMPDH. They were tested for anticancer activity in-vitro and were also shown to possess immunosuppressive properties. This review is the first summarizing the synthesis and activity of the mentioned quinolinones.
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Cite this article as:
Hradil P., Hlavac J., Soural M., Hajduch M., Kolar M. and Vecerova R., 3-Hydroxy-2-phenyl-4(1H)-quinolinones as Promising Biologically Active Compounds, Mini-Reviews in Medicinal Chemistry 2009; 9 (6) . https://dx.doi.org/10.2174/138955709788452720
DOI https://dx.doi.org/10.2174/138955709788452720 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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