Abstract
The synthesis of C-12 deuterated and tritiated deoxoartemisinins is described. Tritiated deoxoartemisinin which could be incubated with the protein of Plasmodium falciparum for binding mechanism study was obtained by direct reduction of the carbonyl group of artemisinin using NaBT4 and BF3×Et2O in dried THF.
Keywords: sodium borohydride, deuterium labeling, tritium labeling, malaria, artemisinin, deoxoartemisinin
Medicinal Chemistry
Title: Synthesis of 12-Deuterated and Tritiated Deoxoartemisinins
Volume: 1 Issue: 2
Author(s): Mankil Jung and Kyunghoon Lee
Affiliation:
Keywords: sodium borohydride, deuterium labeling, tritium labeling, malaria, artemisinin, deoxoartemisinin
Abstract: The synthesis of C-12 deuterated and tritiated deoxoartemisinins is described. Tritiated deoxoartemisinin which could be incubated with the protein of Plasmodium falciparum for binding mechanism study was obtained by direct reduction of the carbonyl group of artemisinin using NaBT4 and BF3×Et2O in dried THF.
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Cite this article as:
Jung Mankil and Lee Kyunghoon, Synthesis of 12-Deuterated and Tritiated Deoxoartemisinins, Medicinal Chemistry 2005; 1 (2) . https://dx.doi.org/10.2174/1573406053175319
DOI https://dx.doi.org/10.2174/1573406053175319 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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