Abstract
The endothelium entered the field of regenerative medicine with the discovery of endothelial progenitor cells (EPCs). These cells participate in endothelial homeostasis and are actively involved in physiological and pathological neovascularization. Despite the unresolved discussion about the very phenotype of these cells, great efforts have been devoted to study the role of EPCs in cardiovascular diseases. EPCs are very rare in peripheral circulation and are further reduced in association with cardiovascular diseases. Therefore, finding therapies to improve EPCs could unleash the way to promising cell-based therapies. Ex-vivo expansion of EPCs is a critical step to augment EPCs number, but it still needs several improvements. An alternative strategy to partially overcome these limitations is to target EPCs with available drugs. In this review we will discuss how disparate pharmacological compounds have been used to improve EPCs number and functions.
Keywords: Endothelium, stem cells, regeneration, treatment
Cardiovascular & Hematological Disorders-Drug Targets
Title: Pharmacologic Targeting of Endothelial Progenitor Cells
Volume: 10 Issue: 1
Author(s): Mattia Albiero, Lisa Menegazzo, Angelo Avogaro and Gian P. Fadini
Affiliation:
Keywords: Endothelium, stem cells, regeneration, treatment
Abstract: The endothelium entered the field of regenerative medicine with the discovery of endothelial progenitor cells (EPCs). These cells participate in endothelial homeostasis and are actively involved in physiological and pathological neovascularization. Despite the unresolved discussion about the very phenotype of these cells, great efforts have been devoted to study the role of EPCs in cardiovascular diseases. EPCs are very rare in peripheral circulation and are further reduced in association with cardiovascular diseases. Therefore, finding therapies to improve EPCs could unleash the way to promising cell-based therapies. Ex-vivo expansion of EPCs is a critical step to augment EPCs number, but it still needs several improvements. An alternative strategy to partially overcome these limitations is to target EPCs with available drugs. In this review we will discuss how disparate pharmacological compounds have been used to improve EPCs number and functions.
Export Options
About this article
Cite this article as:
Albiero Mattia, Menegazzo Lisa, Avogaro Angelo and Fadini P. Gian, Pharmacologic Targeting of Endothelial Progenitor Cells, Cardiovascular & Hematological Disorders-Drug Targets 2010; 10 (1) . https://dx.doi.org/10.2174/187152910790780087
DOI https://dx.doi.org/10.2174/187152910790780087 |
Print ISSN 1871-529X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4063 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Hematopoietic Stem Cells Therapies
Current Stem Cell Research & Therapy Macrophages: Promising Targets for the Treatment of Atherosclerosis
Current Vascular Pharmacology Endothelial Activation. Sliding Door to Atherosclerosis
Current Pharmaceutical Design Diabetic Cardiomyopathy and Oxidative Stress: Role of Antioxidants
Cardiovascular & Hematological Agents in Medicinal Chemistry Novel Risk Factors Related to Stable Angina
Current Pharmaceutical Design Tenofovir-Related Nephropathies in HIV-Infected Patients
Current Vascular Pharmacology The Changing Face of HIV/AIDS in Treated Patients
Current HIV Research Chemokines and Atherosclerotic Plaque Progression: Towards Therapeutic Targeting?
Current Pharmaceutical Design The Association of Very High Hair Manganese Accumulation and High Oxidative Stress in Mongolian People
Current Aging Science Polyphenols Beyond Barriers: A Glimpse into the Brain
Current Neuropharmacology Molecular Pharmacological Approaches to Effects of Capsaicinoids and of Classical Antisecretory Drugs on Gastric Basal Acid Secretion and on Indomethacin-Induced Gastric Mucosal Damage in Human Healthy Subjects (Mini Review)
Current Pharmaceutical Design Importance of Assessing the Effect of Statins on the Function of High- Density Lipoproteins on Coronary Plaque
Cardiovascular & Hematological Disorders-Drug Targets Therapeutics Targeting Nogo-A Hold Promise for Stroke Restoration
CNS & Neurological Disorders - Drug Targets An Insight to Colon Targeted Drug Delivery System
Drug Delivery Letters Crosstalk between Behavior and Immune System During the Prodromal Stages of Alzheimer`s Disease
Current Pharmaceutical Design Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement
Mini-Reviews in Organic Chemistry Passive Smoking, Endothelial Dysfunction and Related Markers in Healthy Individuals: An Update
Current Hypertension Reviews Can Imaging Techniques Identify Smoking-Related Cardiovascular Disease?
Current Pharmaceutical Design The Start of a New Era for Stroke Treatment: Mechanical Thrombectomy Devices
Current Neurovascular Research Inflammasome and Atherogenesis
Current Pharmaceutical Design