Abstract
Glycosylphosphatidylinositol (GPI) moieties consist of a hydrophobic core (two to three fatty acids attached to phosphatidylinositol) continued by a chain of five hexoses (the glycolinker) that is covalently linked via phosphoethanolamine to the C-terminal amino acid of a long list of mammalian proteins. This glycolipid moiety imparts characteristic membrane properties (diffusion, lateral mobility and clustering) to proteins and the glycolinker component constitutes a molecular motif recognized by lectins, cytokines and bacterial toxins. Due to the saturated acyl chains of its core lipids, GPIs preferentially insert in sphingolipid-rich domains of the plasma membrane outer leaflet, and the capacity of GPIanchored proteins to participate in transmembrane signalling depends on this property. GPI-anchored proteins can be made to associate with membranes and thus offer a therapeutic potential in tumor vaccine preparation and complement protection. Research on the role of GPI-anchored proteins in membrane structure and function has fruitfully contributed to the elaboration of today ’ s prevailing concepts of membrane organization.
Keywords: concanavalin A, tumor necrosis factor alpha, CD59 protein, insulin-receptor substrate, Bacterial Toxins
Current Organic Chemistry
Title: Functional and Structural Roles of GPI Moieties in Mammalian Plasma Membranes
Volume: 11 Issue: 7
Author(s): Daniel C. Hoessli, Sebastien Tauzin, Nasir-ud-Din and Bettina Borisch
Affiliation:
Keywords: concanavalin A, tumor necrosis factor alpha, CD59 protein, insulin-receptor substrate, Bacterial Toxins
Abstract: Glycosylphosphatidylinositol (GPI) moieties consist of a hydrophobic core (two to three fatty acids attached to phosphatidylinositol) continued by a chain of five hexoses (the glycolinker) that is covalently linked via phosphoethanolamine to the C-terminal amino acid of a long list of mammalian proteins. This glycolipid moiety imparts characteristic membrane properties (diffusion, lateral mobility and clustering) to proteins and the glycolinker component constitutes a molecular motif recognized by lectins, cytokines and bacterial toxins. Due to the saturated acyl chains of its core lipids, GPIs preferentially insert in sphingolipid-rich domains of the plasma membrane outer leaflet, and the capacity of GPIanchored proteins to participate in transmembrane signalling depends on this property. GPI-anchored proteins can be made to associate with membranes and thus offer a therapeutic potential in tumor vaccine preparation and complement protection. Research on the role of GPI-anchored proteins in membrane structure and function has fruitfully contributed to the elaboration of today ’ s prevailing concepts of membrane organization.
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Cite this article as:
Hoessli C. Daniel, Tauzin Sebastien, Nasir-ud-Din and Borisch Bettina, Functional and Structural Roles of GPI Moieties in Mammalian Plasma Membranes, Current Organic Chemistry 2007; 11 (7) . https://dx.doi.org/10.2174/138527207780598783
DOI https://dx.doi.org/10.2174/138527207780598783 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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