Abstract
Fluorine atom has been used extensively to modulate the properties of various peptide-like compounds to modulate enzyme activities such as proteases. Fluorinated functionalities such as trifluoromethyl group, difluoromethyl group, fluoromethyl moiety and recently -CHF-S- were investigated. This article discusses important fluorine containing peptidomimetics, synthetic strategies, and the modulation of enzymic activities.
Keywords: Fluoropeptidomimetics, fluorine substitution, peptidomimicry, protease inhibitors
Mini-Reviews in Organic Chemistry
Title: Fluorine Containing Molecules for Peptidomimicry: A Chemical Act to Modulate Enzymatic Activity
Volume: 3 Issue: 2
Author(s): C. E. Oyiliagu, M. Novalen and L. P. Kotra
Affiliation:
Keywords: Fluoropeptidomimetics, fluorine substitution, peptidomimicry, protease inhibitors
Abstract: Fluorine atom has been used extensively to modulate the properties of various peptide-like compounds to modulate enzyme activities such as proteases. Fluorinated functionalities such as trifluoromethyl group, difluoromethyl group, fluoromethyl moiety and recently -CHF-S- were investigated. This article discusses important fluorine containing peptidomimetics, synthetic strategies, and the modulation of enzymic activities.
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Cite this article as:
Oyiliagu E. C., Novalen M. and Kotra P. L., Fluorine Containing Molecules for Peptidomimicry: A Chemical Act to Modulate Enzymatic Activity, Mini-Reviews in Organic Chemistry 2006; 3 (2) . https://dx.doi.org/10.2174/157019306776819235
DOI https://dx.doi.org/10.2174/157019306776819235 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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