Title:Microwave-Induced Ugi-Four Component Reactions: Synthesis of New Hetero- Steroid-Amino Acid Conjugates
VOLUME: 17 ISSUE: 8
Author(s):Preetismita Borah*, Biswa Mohan Sahoo, Vhatkar Dattatraya Shivling and Bimal Krishna Banik
Affiliation:CSIR-Central Scientific Instruments Organization, Chandigarh, Roland Institute of Pharmaceutical Sciences, Berhampur- 760010, Odisha, CSIR-Central Scientific Instruments Organization, Chandigarh, Prince Mohammad Bin Fahd University, Al Khobar
Keywords:Microwave, Ugi-4CR, steroidal amines, amino acids, heterosteroid conjugates, aza-steroids.
Abstract:
Background: Aza-steroids are an important class of compounds because of their numerous biological
activities. The hetero steroids have different hydrogen bonding ability and hydrophobicity in comparison to steroids.
Materials and Methods: Microwave-induced synthesis of a novel type of hybrid hetero-steroid amine conjugates,
following Ugi-four component reactions of steroidal amines with alanine and valine methyl esters as amino
acid residues is described. Specifically, hetero-steroid-amino acid conjugate based on D-ring fused hetero steroidal
amine, hetero-steroid-amino acid conjugate based on A-ring hetero steroidal amine, and hetero-steroidamino
acid conjugate based on B-ring hetero steroidal amine are synthesized.
Results and Discussion: The yield of the products under microwave-induced process was considerably higher
than that obtained by the conventional method. In contrast to the conventional method for the synthesis of these
molecules, microwave-induced method has several advantages.
Conclusion: These include rapid reaction, a superior yield of the product, minimum side reaction, and economical
microwave-induced process.
