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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Macrolactin Antibiotics: Amazing Natural Products

Author(s): Aurelio Ortiz and Estibaliz Sansinenea*

Volume 20, Issue 7, 2020

Page: [584 - 600] Pages: 17

DOI: 10.2174/1389557519666191205124050

Price: $65

Abstract

The resistance among various microbial species (infectious agents) to different antimicrobial drugs has emerged as a cause of serious public health problem all over the world. In this sense, natural products have been a rich source of compounds for drug discovery with antibiotic activity. Macrolactins are amazing structures which have antibiotic activity against some clinically relevant pathogens. In addition, they have anti-inflammatory, antifungal, antimicrobial, and antitumor activities. They are macrolides containing 24-membered lactone ring with some differences in their chemical structures. The synthesis of these compounds is a difficult task which has attracted attention of researchers; however few syntheses have been reported. In this review, the isolation of all reported macrolactins, their syntheses and biological activities are revisited.

Keywords: Macrolactins, antibiotics, natural products, microorganisms, isolation, biological activities.

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Graphical Abstract

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