Abstract
Background: Enormous success of antitumor agent cisplatin initiated interest in other organometallic complexes. A subclass of organometallic compounds termed metallocenes, characterized by a transition metal central atom (M) bound to cyclopentadienide (Cp-/[C5H5]-) ligands with the basic formula Cp2M, has gained increasing interest as promising anticancer agents.
Objectives: This review summarizes the progress in the development of organometallic titaniumbased compounds focusing primarily on the evaluation of their cytotoxic activity and mechanism of action in relation to potential utilization as anticancer drugs. Results: Metallocenes bearing titanium as central atom were sorted according to their structure and modifications and their anticancer activity is further discussed. Conclusion: Titanocenes represent family of promising compounds exerting cytostatic activity. We suggest that their application not only as separate agents, but also in combination with newly developed carriers, e.g. nanomaterials, may lead to improvement of their delivery into tumor cells and following utilization in cancer treatment.Keywords: Chemotherapy, cisplatin, clinical trials, organometallic compounds, titanocene compounds, titanocene dichloride.
Medicinal Chemistry
Title:Titanocenes as Anticancer Agents: Recent Insights
Volume: 13 Issue: 4
Author(s): Hana Skoupilova, Roman Hrstka*Martin Bartosik*
Affiliation:
- Masaryk Memorial Cancer Institute, RECAMO, Zluty kopec 7, 656 53, Brno,Czech Republic
- RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno,Czech Republic
Keywords: Chemotherapy, cisplatin, clinical trials, organometallic compounds, titanocene compounds, titanocene dichloride.
Abstract: Background: Enormous success of antitumor agent cisplatin initiated interest in other organometallic complexes. A subclass of organometallic compounds termed metallocenes, characterized by a transition metal central atom (M) bound to cyclopentadienide (Cp-/[C5H5]-) ligands with the basic formula Cp2M, has gained increasing interest as promising anticancer agents.
Objectives: This review summarizes the progress in the development of organometallic titaniumbased compounds focusing primarily on the evaluation of their cytotoxic activity and mechanism of action in relation to potential utilization as anticancer drugs. Results: Metallocenes bearing titanium as central atom were sorted according to their structure and modifications and their anticancer activity is further discussed. Conclusion: Titanocenes represent family of promising compounds exerting cytostatic activity. We suggest that their application not only as separate agents, but also in combination with newly developed carriers, e.g. nanomaterials, may lead to improvement of their delivery into tumor cells and following utilization in cancer treatment.Export Options
About this article
Cite this article as:
Skoupilova Hana, Hrstka Roman*, Bartosik Martin*, Titanocenes as Anticancer Agents: Recent Insights, Medicinal Chemistry 2017; 13 (4) . https://dx.doi.org/10.2174/1573406412666161228113650
DOI https://dx.doi.org/10.2174/1573406412666161228113650 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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Carbohydrates in Computational and Medicinal Chemistry
Carbohydrates are the most essential organic molecules and are involved in the maintenance of various physiological and metabolic processes in living organisms. Carbohydrate-based compounds have come to the attention of researchers because of their significant contributions to biological functions, such as cell development and cell proliferation, connections between several cells, ...read more
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Scope of the Thematic Issue: Correlation between structure and function is one of the important aspects of the success of anti-cancer compounds associated with their structure-activity interactions, physiology, biochemical, molecular, and genetic processes. Overcoming these obstacles is key to obtaining further insights into developments in rational drug design, bioorganic chemistry, ...read more
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