Abstract
Arjunolic acid (AA) is a triterpenoid saponin isolated mainly from Terminalia arjuna bark. Arjunolic acid is associated with the various important physiological functions viz. antioxidant, antimicrobial, cardioprotective, hepatoprotective, and plays important role in supramolecular chemistry, etc. Arjunolic acid exhibits important function in maintaining the level of various antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GPx), level of cellular metabolites, reduced glutathione (GSH), oxidized glutathione (GSSG) and thereby reduces the oxidative stress. Its protective effect on liver, pancreas and kidney has also been the key property of arjunolic acid. Hence, arjunolic acid has potential to treat various disorders and this review may provide valuable information about arjunolic acid.
Keywords: Oxidative stress, arjunolic acid, Terminalia arjuna, reactive oxygen species (ROS), reactive nitrogen species (RON).
Current Organic Chemistry
Title:Arjunolic Acid: A Promising Antioxidant Moiety with Diverse Biological Applications
Volume: 21 Issue: 4
Author(s): Arun Nanda, S. H. Ansari and Sarita Khatkar
Affiliation:
Keywords: Oxidative stress, arjunolic acid, Terminalia arjuna, reactive oxygen species (ROS), reactive nitrogen species (RON).
Abstract: Arjunolic acid (AA) is a triterpenoid saponin isolated mainly from Terminalia arjuna bark. Arjunolic acid is associated with the various important physiological functions viz. antioxidant, antimicrobial, cardioprotective, hepatoprotective, and plays important role in supramolecular chemistry, etc. Arjunolic acid exhibits important function in maintaining the level of various antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GPx), level of cellular metabolites, reduced glutathione (GSH), oxidized glutathione (GSSG) and thereby reduces the oxidative stress. Its protective effect on liver, pancreas and kidney has also been the key property of arjunolic acid. Hence, arjunolic acid has potential to treat various disorders and this review may provide valuable information about arjunolic acid.
Export Options
About this article
Cite this article as:
Nanda Arun, Ansari H. S. and Khatkar Sarita, Arjunolic Acid: A Promising Antioxidant Moiety with Diverse Biological Applications, Current Organic Chemistry 2017; 21 (4) . https://dx.doi.org/10.2174/1385272820666161017164404
DOI https://dx.doi.org/10.2174/1385272820666161017164404 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Past and Recent Progress of Molecular Imaging Probes for β-Amyloid Plaques in the Brain
Current Medicinal Chemistry Oxidative and Nitrosative Stress and Immune-inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)
Current Neuropharmacology Magnetic Nanoparticles in Brain Disease Diagnosis and Targeting Drug Delivery
Current Nanoscience Alzheimer’s Disease and Parkinson’s Disease: A Review of Current Treatment Adopting a Nanotechnology Approach
Current Pharmaceutical Design Drug Abuse, Brain Calcification and Glutamate-Induced Neurodegeneration
Current Drug Abuse Reviews Programmed Axon Death, Synaptic Dysfunction and the Ubiquitin Proteasome System
Current Drug Targets - CNS & Neurological Disorders Alcohol and Smoking Mediated Oxidative Stress in Organ Toxicities: Role of Cytochrome P450 Systems
Mini-Reviews in Organic Chemistry Insulin Resistance in Brain and Possible Therapeutic Approaches
Current Vascular Pharmacology Neuroprotective Methodologies of Co-Enzyme Q10 Mediated Brain Hemorrhagic Treatment: Clinical and Pre-Clinical Findings
CNS & Neurological Disorders - Drug Targets Angiogenesis-regulating microRNAs and Ischemic Stroke
Current Vascular Pharmacology A Recent Look into Natural Products that have Potential to Inhibit Cholinesterases and Monoamine Oxidase B: Update for 2010-2019
Combinatorial Chemistry & High Throughput Screening Addressing Alzheimer’s Disease and Cognitive Loss through Autophagy
Current Neurovascular Research The Gastrin-Releasing Peptide Receptor as a Therapeutic Target in Central Nervous System Disorders
Recent Patents on CNS Drug Discovery (Discontinued) Patent Selections:
Recent Patents on Regenerative Medicine Protein Aggregation and Defective RNA Metabolism as Mechanisms for Motor Neuron Damage
CNS & Neurological Disorders - Drug Targets Oxidative Stress and Amyloid Beta Toxicity in Alzheimer’s Disease: Intervention in a Complex Relationship by Antioxidants
Current Medicinal Chemistry Scientific Basis for the Use of Indian Ayurvedic Medicinal Plants in the Treatment of Neurodegenerative Disorders: 1. Ashwagandha
Central Nervous System Agents in Medicinal Chemistry Applications of Lentiviral Vectors for Biology and Gene Therapy of Neurological Disorders
Current Gene Therapy Improving Brain Drug Targeting Through Exploitation of The Nose-to- Brain Route: A Physiological and Pharmacokinetic Perspective
Current Drug Delivery Alkaloids Pharmacological Activities - Prospects for the Development of Phytopharmaceuticals for Neurodegenerative Diseases
Current Pharmaceutical Biotechnology