Abstract
The article is an up-to-date review of the state-of-the art in the challenging field of smart synthetic polymer nanocarriers, presenting the most relevant achievements in the area, with a special emphasis on the outstanding potential of these nanovehicles to be used as multifunctional devices capable to deliver their cargo to a specific targeted area in the human body and to release it in a well controlled fashion. Stimuli-responsive nano drug delivery systems are presented according to a classification that takes into account the endogenous or exogenous nature of the stimuli. Each category is amply illustrated by carefully selected examples of the most impressive achievements. The endogenous stimuli category is fully described by presentation of pH, redox potential, and enzyme-responsive nanocarriers. From the category of exogenous stimuliresponsive nanomaterials, we focused our attention on temperature, light and magnetic sensitive nanocarriers.
Keywords: Dual-responsive, Enzyme, Magnetic, pH, Pharmaceutical nanotechnology, Photo, Programmed drug delivery, Redox potential, Temperature, Triggered release.
Current Topics in Medicinal Chemistry
Title:Smart Synthetic Polymer Nanocarriers for Controlled and Site-Specific Drug Delivery
Volume: 15 Issue: 15
Author(s): Paul Catalin Balaure and Alexandru Mihai Grumezescu
Affiliation:
Keywords: Dual-responsive, Enzyme, Magnetic, pH, Pharmaceutical nanotechnology, Photo, Programmed drug delivery, Redox potential, Temperature, Triggered release.
Abstract: The article is an up-to-date review of the state-of-the art in the challenging field of smart synthetic polymer nanocarriers, presenting the most relevant achievements in the area, with a special emphasis on the outstanding potential of these nanovehicles to be used as multifunctional devices capable to deliver their cargo to a specific targeted area in the human body and to release it in a well controlled fashion. Stimuli-responsive nano drug delivery systems are presented according to a classification that takes into account the endogenous or exogenous nature of the stimuli. Each category is amply illustrated by carefully selected examples of the most impressive achievements. The endogenous stimuli category is fully described by presentation of pH, redox potential, and enzyme-responsive nanocarriers. From the category of exogenous stimuliresponsive nanomaterials, we focused our attention on temperature, light and magnetic sensitive nanocarriers.
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Cite this article as:
Catalin Balaure Paul and Mihai Grumezescu Alexandru, Smart Synthetic Polymer Nanocarriers for Controlled and Site-Specific Drug Delivery, Current Topics in Medicinal Chemistry 2015; 15 (15) . https://dx.doi.org/10.2174/1568026615666150414115852
DOI https://dx.doi.org/10.2174/1568026615666150414115852 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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