Abstract
Despite affecting around 8 million people worldwide and representing an economic burden above $7 billion/ year, currently approved medications to treat Chagas disease are still limited to two drugs, nifurtimox and benznidazole, which were developed more than 40 years ago and present important efficacy and safety limitations. Drug repositioning (i.e. finding second or further therapeutic indications for known drugs) has raised considerable interest within the international drug development community. There are many explanations to the current interest on drug repositioning including the possibility to partially circumvent clinical trials and the consequent saving in time and resources. It has been suggested as a particular attractive approach for the development of novel therapeutics for neglected diseases, which are usually driven by public or non-profit organizations. Here we review current computer-guided approaches to drug repositioning and reports on drug repositioning stories oriented to Chagas disease, with a focus on computer-guided drug repositioning campaigns.
Keywords: Chagas disease, computer-guided drug repositioning, drug repositioning, drug repurposing, neglected diseases, indication expansion, high-throughput drug repurposing.
Mini-Reviews in Medicinal Chemistry
Title:High-throughput Drug Repositioning for the Discovery of New Treatments for Chagas Disease
Volume: 15 Issue: 3
Author(s): Carolina L. Bellera, Maria L. Sbaraglini, Dario E. Balcazar, Laura Fraccaroli, M. Cristina Vanrell, A. Florencia Casassa, Carlos A. Labriola, Patricia S. Romano, Carolina Carrillo and Alan Talevi
Affiliation:
Keywords: Chagas disease, computer-guided drug repositioning, drug repositioning, drug repurposing, neglected diseases, indication expansion, high-throughput drug repurposing.
Abstract: Despite affecting around 8 million people worldwide and representing an economic burden above $7 billion/ year, currently approved medications to treat Chagas disease are still limited to two drugs, nifurtimox and benznidazole, which were developed more than 40 years ago and present important efficacy and safety limitations. Drug repositioning (i.e. finding second or further therapeutic indications for known drugs) has raised considerable interest within the international drug development community. There are many explanations to the current interest on drug repositioning including the possibility to partially circumvent clinical trials and the consequent saving in time and resources. It has been suggested as a particular attractive approach for the development of novel therapeutics for neglected diseases, which are usually driven by public or non-profit organizations. Here we review current computer-guided approaches to drug repositioning and reports on drug repositioning stories oriented to Chagas disease, with a focus on computer-guided drug repositioning campaigns.
Export Options
About this article
Cite this article as:
Bellera L. Carolina, Sbaraglini L. Maria, Balcazar E. Dario, Fraccaroli Laura, Vanrell Cristina M., Casassa Florencia A., Labriola A. Carlos, Romano S. Patricia, Carrillo Carolina and Talevi Alan, High-throughput Drug Repositioning for the Discovery of New Treatments for Chagas Disease, Mini-Reviews in Medicinal Chemistry 2015; 15 (3) . https://dx.doi.org/10.2174/138955751503150312120208
DOI https://dx.doi.org/10.2174/138955751503150312120208 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The In Silico Insights of α-Adrenergic Receptors Over the Last Decade: Methodological Approaches and Structural Features of the 3D Models
Current Topics in Medicinal Chemistry Computational Biology and Drug Discovery: From Single-Target to Network Drugs
Current Bioinformatics Role of Topological, Electronic, Geometrical, Constitutional and Quantum Chemical Based Descriptors in QSAR: mPGES-1 as a Case Study
Current Topics in Medicinal Chemistry Therapeutic Antibodies
Current Molecular Medicine A Versatile and Efficient Cu-Catalyzed N-Arylation of Aromatic Cyclic Secondary Amines with Aryl Halides
Letters in Organic Chemistry Phenylpyazoleanilides as a Potent Inhibitor of IL-15 Dependent T Cell Proliferation. Part 1: A New Class of Orally Available Immunomodulators
Letters in Drug Design & Discovery Medicinal Chemistry Insights into Novel HDAC Inhibitors: An Updated Patent Review (2012-2016)
Recent Patents on Anti-Cancer Drug Discovery Economic Fluctuations: The Aftermath of COVID 19 Pandemic
Coronaviruses Triazene Compounds in the Treatment of Acute Myeloid Leukemia: A Short Review and a Case Report
Current Medicinal Chemistry Editorial [Hot Topic: New Advances in Intensive Care Unit-Acquired Infection (Guest Editor: Saad Nseir)]
Infectious Disorders - Drug Targets A Comprehensive Review on SAR of Curcumin
Mini-Reviews in Medicinal Chemistry Recent Developments of Metal and Metal Oxide Nanocatalysts in Organic Synthesis
Mini-Reviews in Medicinal Chemistry Cyclosporin A: A Therapeutic Strategy in Allergic Diseases
Letters in Drug Design & Discovery Novel N-mustard-benzimidazoles/benzothiazoles Hybrids, Synthesis and Anticancer Evaluation
Anti-Cancer Agents in Medicinal Chemistry Reproduction in Couples with Chronic Viral Infections
Current Women`s Health Reviews Hydroxychloroquine and Azithromycin Combination in the Management of COVID-19 Infection: Safety and Effectiveness Challenges
Current Drug Safety Xolair in Asthma Therapy: An Overview
Inflammation & Allergy - Drug Targets (Discontinued) Aurora Kinase Inhibitors in Head and Neck Cancer
Current Topics in Medicinal Chemistry Antiviral Potential of Medicinal Plants for the COVID-19
Anti-Infective Agents Chinese Medicinal Herbs as Source of Antioxidant Compounds – Where Tradition Meets the Future
Current Medicinal Chemistry