Abstract
Non-Communicable Diseases (NCDs) are among the most pressing global health problems of the twenty-first century. Their rising incidence and prevalence is linked to severe morbidity and mortality, and they are putting economic and managerial pressure on healthcare systems around the world. Moreover, NCDs are impeding healthy aging by negatively affecting the quality of life of a growing number of the global population. NCDs result from the interaction of various genetic, environmental and habitual factors, and cluster in complex ways, making the complex identification of resulting phenotypes not only difficult, but also a top research priority. The degree of complexity required to interpret large patient datasets generated by advanced high-throughput functional genomics assays has now increased to the point that novel computational biology approaches are essential to extract information that is relevant to the clinical decision-making process. Consequently, system-level models that interpret the interactions between extensive tissues, cellular and molecular measurements and clinical features are also being created to identify new disease phenotypes, so that disease definition and treatment are optimized, and novel therapeutic targets discovered. Likewise, Systems Medicine (SM) platforms applied to extensively-characterized patients provide a basis for more targeted clinical trials, and represent a promising tool to achieve better prevention and patient care, thereby promoting healthy aging globally. The present paper: (1) reviews the novel systems approaches to NCDs; (2) discusses how to move efficiently from Systems Biology to Systems Medicine; and (3) presents the scientific and clinical background of the San Raffaele Systems Medicine Platform.
Keywords: Systems medicine, non-communicable diseases, P4 medicine, systems biology.
Current Pharmaceutical Design
Title:A Systems Medicine Clinical Platform for Understanding and Managing Non- Communicable Diseases
Volume: 20 Issue: 38
Author(s): Paolo Maria Rossini, Achille Lococo, Dieter Maier, Frederick Marcus, Stefano Margaritora, Camillo Marra, Gianfranco Minati, Monica Neri, Franco Pasqua, Christophe Pison, Christian Pristipino, Joseph Roca, Giuseppe Rosano, Filippo Lococo, Patrizia Russo, Gianluca Salinaro, Shani Shenhar, Hermona Soreq, Peter J. Sterk, Fabrizio Stocchi, Margherita Torti, Maurizio Volterrani, Emiel F.M. Wouters, Alessandra Frustaci, Stefano Bonassi, Nikolai Daraselia, Charles Auffray, Alvar Agusti, Giovanni Apolone, Rudi Balling, Piero Barbanti, Alfonso Bellia, Stefania Boccia, Jean Bousquet, Vittorio Cardaci, Mario Cazzola, Valentina Dall'Armi, Alfredo Cesario, Lucio Da Ros, Alessandra Del Bufalo, Giuseppe Ducci, Luigi Ferri, Massimo Fini, Chiara Fossati, Gianfranco Gensini, Pierluigi Maria Granone, James Kinross, Davide Lauro and Gerland Lo Cascio
Affiliation:
Keywords: Systems medicine, non-communicable diseases, P4 medicine, systems biology.
Abstract: Non-Communicable Diseases (NCDs) are among the most pressing global health problems of the twenty-first century. Their rising incidence and prevalence is linked to severe morbidity and mortality, and they are putting economic and managerial pressure on healthcare systems around the world. Moreover, NCDs are impeding healthy aging by negatively affecting the quality of life of a growing number of the global population. NCDs result from the interaction of various genetic, environmental and habitual factors, and cluster in complex ways, making the complex identification of resulting phenotypes not only difficult, but also a top research priority. The degree of complexity required to interpret large patient datasets generated by advanced high-throughput functional genomics assays has now increased to the point that novel computational biology approaches are essential to extract information that is relevant to the clinical decision-making process. Consequently, system-level models that interpret the interactions between extensive tissues, cellular and molecular measurements and clinical features are also being created to identify new disease phenotypes, so that disease definition and treatment are optimized, and novel therapeutic targets discovered. Likewise, Systems Medicine (SM) platforms applied to extensively-characterized patients provide a basis for more targeted clinical trials, and represent a promising tool to achieve better prevention and patient care, thereby promoting healthy aging globally. The present paper: (1) reviews the novel systems approaches to NCDs; (2) discusses how to move efficiently from Systems Biology to Systems Medicine; and (3) presents the scientific and clinical background of the San Raffaele Systems Medicine Platform.
Export Options
About this article
Cite this article as:
Rossini Maria Paolo, Lococo Achille, Maier Dieter, Marcus Frederick, Margaritora Stefano, Marra Camillo, Minati Gianfranco, Neri Monica, Pasqua Franco, Pison Christophe, Pristipino Christian, Roca Joseph, Rosano Giuseppe, Lococo Filippo, Russo Patrizia, Salinaro Gianluca, Shenhar Shani, Soreq Hermona, Sterk J. Peter, Stocchi Fabrizio, Torti Margherita, Volterrani Maurizio, Wouters F.M. Emiel, Frustaci Alessandra, Bonassi Stefano, Daraselia Nikolai, Auffray Charles, Agusti Alvar, Apolone Giovanni, Balling Rudi, Barbanti Piero, Bellia Alfonso, Boccia Stefania, Bousquet Jean, Cardaci Vittorio, Cazzola Mario, Dall'Armi Valentina, Cesario Alfredo, Ros Da Lucio, Bufalo Del Alessandra, Ducci Giuseppe, Ferri Luigi, Fini Massimo, Fossati Chiara, Gensini Gianfranco, Granone Maria Pierluigi, Kinross James, Lauro Davide and Cascio Lo Gerland, A Systems Medicine Clinical Platform for Understanding and Managing Non- Communicable Diseases, Current Pharmaceutical Design 2014; 20 (38) . https://dx.doi.org/10.2174/1381612820666140314130449
DOI https://dx.doi.org/10.2174/1381612820666140314130449 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Activation of Macrophages: Establishing a Role for Polysaccharides in Drug Delivery Strategies Envisaging Antibacterial Therapy
Current Pharmaceutical Design Use of Grape Polyphenols for Promoting Human Health: A Review of Patents
Recent Patents on Food, Nutrition & Agriculture Current Genomics in Cardiovascular Medicine
Current Genomics Epsilon Waves as an Extreme Form of Depolarization Delay: Focusing on the Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia
Current Cardiology Reviews Modulation of Energy Intake and Expenditure Due to Habitual Physical Exercise
Current Pharmaceutical Design Discovery of a Novel Anti-Cancer Agent Targeting Both Topoisomerase I & II as Well as Telomerase Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo: Cinnamomum verum Component Cuminaldehyde
Current Cancer Drug Targets Heart Failure Models: Traditional and Novel Therapy
Current Vascular Pharmacology Regulation of Inflammation and Myocardial Fibrosis in Experimental Autoimmune Myocarditis
Inflammation & Allergy - Drug Targets (Discontinued) Targeting Adenosine Signaling to Treatment of Diabetic Nephropathy
Current Drug Targets Codon Usage Biases in Alzheimers Disease and Other Neurodegenerative Diseases
Protein & Peptide Letters Drug-Related Cardiotoxicity for the Treatment of Haematological Malignancies in Elderly
Current Pharmaceutical Design Role of Vasa Vasorum in Arterial Disease: A Re-emerging Factor
Current Cardiology Reviews Beneficial Effects of Bioactive Phospholipids: Genomic Bases
Current Nutrition & Food Science Genetic Studies of Type 2 Diabetes in South Asians: A Systematic Overview
Current Diabetes Reviews Nonalcoholic Fatty Liver Disease and Cardiovascular Disease
Current Pharmaceutical Design Adequacy of Quality Assurance Programs for a Corn Meal Production Unit
The Natural Products Journal Dietary Nitrite in Nitric Oxide Biology: A Redox Interplay with Implications for Pathophysiology and Therapeutics
Current Drug Targets Synthesis of Cyclodextrin-based Adsorbents and its Application for Organic Pollutant Removal from Water
Current Organic Chemistry From Bone Marrow to Cardiac Atrial Appendage Stem Cells for Cardiac Repair: A Review
Current Medicinal Chemistry Ghrelin in Obesity, Physiological and Pharmacological Considerations
Mini-Reviews in Medicinal Chemistry