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Review Article

有关重要热带感染的最新理论研究

卷 27, 期 5, 2020

页: [795 - 834] 页: 40

弟呕挨: 10.2174/0929867326666190711121418

价格: $65

摘要

被忽视的热带病（NTD）构成了与贫困密切相关的一组疾病，在贫困的环境中盛行，在热带地区表现出最佳重叠的地区最容易thr壮成长。它们包括几种疾病，症状因疾病而异，通常是由于极度疼痛和无尽的苦难造成的，这些疾病使人口陷入贫困，永久性残疾和死亡。它们影响了全世界超过10亿人；主要生活在热带和亚热带气候的贫困人口中。在这篇评论中，提出了几种互补的计算机方法。包括确定新的治疗靶标，新的活性机制，小分子文库的高通量筛选以及计算机定量结构与活性之间的关系以及最近的分子对接研究。针对睡眠病，美国锥虫病，利什曼病和血吸虫病感染的当前和积极的研究有望在不久的将来导致针对这些寄生虫形式的被忽视的热带病（NTD）的治疗，更安全，更有效，成本更低且用途更广。

关键词: 被忽视的热带病，利什曼病，克鲁斯锥虫，布鲁氏锥虫，恰加斯病，计算机病。

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