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Review Article

药用金属配合物的形态：溶液平衡与药物性质的关系

卷 26, 期 4, 2019

页: [580 - 606] 页: 27

弟呕挨: 10.2174/0929867325666180307113435

价格: $65

摘要

本文讨论了必需和有毒金属离子，具有生物或药用活性的金属配合物的生物特性，以强调金属离子在生物环境中分布的重要性。 存在于不同器官/隔室/流体/细胞中的化学物质的确切知识可提供关于金属离子或候选药物金属络合物的药代动力学性质和生物学效应的基本信息。 首先讨论血清中必需和有毒金属离子的转运，然后描述几种具有药用价值的重要金属配合物的生物分布，如（i）抗癌，（ii）胰岛素增强和（iii）MRI 生物体液中的造影剂。

关键词: 化学平衡，溶液稳定性，血清蛋白质，建模计算，治疗性金属药物，物种分布。

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