Review Article

DNA双链断裂修复 - 相关的合成致死率

卷 26, 期 8, 2019

页: [1446 - 1482] 页: 37

弟呕挨: 10.2174/0929867325666180201114306

价格: $65

摘要

癌症是一种异质性疾病,肿瘤之间和肿瘤内部具有高度多样性。我们对其生物学的有限知识导致无效治疗。然而,个性化方法可能是抗癌治疗领域的里程碑。它可以增加对肿瘤起始癌症干细胞(CSC)和癌症祖细胞(CPC)的治疗的特异性,对正常细胞和组织的影响最小。癌细胞携带多种遗传和表观遗传畸变,这可能破坏细胞存活所必需的途径。合成杀伤力的发现为创造有效和个性化的抗肿瘤治疗带来了新的希望。当两个基因或其产物的同时失活导致细胞死亡而任一基因的个体失活不致死时,发生合成致死。许多抗肿瘤疗法的有效性取决于DNA损伤的诱导,因此表达产物对DNA修复途径至关重要的基因异常的肿瘤细胞是合成致死性的有希望的靶标。在这里,我们讨论了DNA双链断裂修复途径缺陷背景下合成致死性的机制方面。此外,我们回顾了利用合成致死性相互作用的临床试验,并讨论了耐药机制。

关键词: DNA修复,双链断裂(DSB),合成致死率,抗癌疗法,放射疗法,PARP。

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