在天然药物中作为生物兼容性载体的磷脂复合物

Title:Phytosomes as Biocompatible Carriers of Natural Drugs

Volume: 24 Issue: 6

关键词: 磷脂复合物、植物磷脂复合物，天然化合物，创新药物释放系统，制备和表征技术，临床和营养使用。

摘要: Natural products have been frequently used as sources of clinical useful pharmaceuticals. However, some intrinsic characteristics of the natural drugs have limited their use, namely their solubility and chemical stability in physiologic mediums. Innovative drug delivery systems may help overcome such limitations, thus providing more effective administration of natural products. Phytosome (Indena SPA, Italy) is one of the most exciting recent delivery technologies that improves the oral bioavailability of the phytopharmaceuticals by their inclusion in equimolar complexes with dietary phospholipids with vesicular shape in aqueous environments. The purpose of this review is to characterize the state of the art of the phytosome as drug delivery system of natural products, including a discussion of the natural drug-phospholipid complex interactions, mechanisms of oral and topical delivery, methods of preparation and phytosome recent applications and patents in the 2006-2016 period.

Cite this article as:

Phytosomes as Biocompatible Carriers of Natural Drugs, Current Medicinal Chemistry 2017; 24 (6) . https://dx.doi.org/10.2174/0929867323666161028160855